769944-72-1

Usage

Uses

Used in Pharmaceutical Industry:
Piperidine, 3-(4-bromophenyl)is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Piperidine, 3-(4-bromophenyl)is employed as a building block for designing and optimizing the structure of new drug candidates. Its reactivity and structural features enable the creation of molecules with desired biological activities and properties.

InChI:InChI=1/C11H14BrN/c12-11-5-3-9(4-6-11)10-2-1-7-13-8-10/h3-6,10,13H,1-2,7-8H2

Upstream product

• 769944-71-0 3-(4-bromophenyl) piperidin-2-one 
• 3973-62-4 3-phenylpiperidine 
• 129013-83-8 3-(4-bromophenyl)pyridine 
• 1008-88-4 3-phenylpyridine 
• 14062-25-0 Ethyl 4-bromophenylacetate 
• 1692-25-7 3-pyridylboronic acid 
• 589-87-7 1,4-bromoiodobenzene 

Downstream Products

• 769944-73-2 tert-butyl 3-(4-bromophenyl)piperidine-1-carboxylate 
• 1338544-06-1 tert-butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 
• 1335523-82-4 4-(3S-piperidine-3-yl)bromobenzene 
• 1476776-55-2 (S)-3-(4-bromophenyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1196713-67-3 2-[4-((3S)-(tertbutoxycarbonyl)piperidin-3-yl)phenyl]-2H-indazole-7-carboxylic acid methyl ester 

Relevant academic research and scientific papers

INDOLO HEPTAMYL OXIME ANALOGUE AS PARP INHIBITOR

Disclosed is a type of indolo heptamyl oxime compounds as a PARP inhibitor. Specifically disclosed are a compound as represented by formula (II) and a pharmaceutically acceptable salt thereof.

A Niraparib intermediate (S)-3 - (4 - bromophenyl) piperidine preparation method (by machine translation)

The invention discloses a Niraparib intermediate (S)- 3 - (4 - bromophenyl) piperidine of preparation method, the method using the bromo ethyl acetate with N - boc - 3 - amino propyl bromide in alkali under the action of the nucleophilic reaction, ring un

Preparation method of niraparib tosilate monohydrate

The invention discloses a preparation method of a compound 2-[4-((3S)-3-piperidyl)phenyl]-2H-indazole-7-formamide tosilate monohydrate. The method includes: carrying out Ulman reaction on 1H-indazole-7-methyl formate and (S)-3-(4-halogenophenyl)piperidine-1-tert-butyl formate to prepare 2-[4-((3S)-3-piperidyl)phenyl]-2H-indazole-7-methyl formate, then under the conditions of ammonia gas and p-toluenesulfonic acid, preparing 2-[4-((3S)-3-piperidyl)phenyl]-2H-indazole-7-formamide tosilate monohydrate. The invention aims to avoid the disadvantages of existing methods, shortens the preparation route, and provides the preparation method of the 2-[4-((3S)-3-piperidyl)phenyl]-2H-indazole-7-formamide tosilate monohydrate with high chiral purity, and the method has the characteristics of mild reaction and easy operation.

TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME

Trycyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.

LINCOSAMIDE DERIVATIVE, AND ANTIBACTERIAL AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT

An objective of the present invention is to provide compounds of formula (I) or their pharmacologically acceptable salts or solvates wherein A represents aryl while R1 represents a five- or six-membered monocyclic heterocyclic group, or A represents a four- to six-membered monocyclic heterocyclic group while R1 represents aryl or a five- or six-membered monocyclic heterocyclic group; R2 represents a hydrogen atom or C1-6 alkyl; R3 represents C1-6 alkyl or C3-6 cycloalkyl-C1-4 alkyl; R4, R5, and R6 represent a hydrogen atom; R7 represents C1-6 alkyl; and m is 1 to 3. The compounds are novel lincosamide derivatives that have a potent activity against resistant Streptococcus pneumoniae. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.