769944-73-2

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester is used as an intermediate for the synthesis of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor. Niraparib is particularly efficacious in treating BRCA-1 and -2 mutant tumors, which are associated with an increased risk of developing certain types of cancer, such as ovarian, breast, and pancreatic cancer.
3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester's role as an intermediate in the production of Niraparib highlights its importance in the pharmaceutical industry, as it contributes to the development of targeted therapies for cancer patients with specific genetic mutations. By inhibiting PARP, Niraparib can help prevent the repair of damaged DNA in cancer cells, leading to cell death and potentially improving the prognosis for patients with BRCA-1 and -2 mutations.

Upstream product

• 1692-25-7 3-pyridylboronic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 106-37-6 1.4-dibromobenzene 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 
• 148763-41-1 1-(tert-butyl) 3-methyl piperidine-1,3-dicarboxylate 
• 129013-83-8 3-(4-bromophenyl)pyridine 
• 769944-72-1 3-(4-bromo-phenyl)-piperidine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 769944-76-5 3-(4-cyclohexylaminophenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1338544-06-1 tert-butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 
• 769944-74-3 3-(4-(4-methylpiperazin-1-yl)-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

INDOLO HEPTAMYL OXIME ANALOGUE AS PARP INHIBITOR

Disclosed is a type of indolo heptamyl oxime compounds as a PARP inhibitor. Specifically disclosed are a compound as represented by formula (II) and a pharmaceutically acceptable salt thereof.

Preparation method of nilaparib intermediate

The preparation method comprises the following steps: in a reaction solvent, a compound 1 and a compound 2 are reacted under the synergistic catalysis of a photocatalyst and Ni catalyst to obtain compound 3, and compound 3 is a nilaparib intermediate. Whe

Conversion of Ester Moieties to 4-Bromophenyl Groups via Electrocyclic Reaction of Dibromocyclopropanes

(Chemical Equation Presented) Conversion of ester moieties into 4-bromophenyl groups was effected by means of a four-step protocol: a Grignard reaction of the ester with allylmagnesium halides, a ring-closing metathesis, dibromocyclopropanation, and an electrocyclic reaction of the dibromocyclopropanes.

TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME

Trycyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.

2, 3, 6-TRISUBSTITUTED-4-PYRIMIDONE DERIVATIVES

A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof; useful for prventive and/or therapeutic treatment of diseass such as neurodegenerative diseases (e.g. Alzheimer disease); wherein Q represents CH or nitrogen atom; R represents a C1-C12 alkyl group; the ring of Formula (I): represents piperazine ring or piperidine ring; each X independently represents a C1-C8 alkyl group, an optionally partially hydrogenated C6-C10 aryl ring, an indan ring or the like; m represents an integer of 1 to 3; each Y independently represents a halogen atom, a hydroxy group, a cyano group, a C1-C6 alkyl group or the like; n represents an integer of 0 to 8; when X and Y or two Y groups are attached on the same carbon atom, they may combine to each other to form a C2-C6 alkylene group.