769944-73-2

Basic information

• Product Name: 3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 3-(4-bromophenyl)piperidine-1-carboxylate;1-Boc-3-(4-BroMophenyl)piperidine;1-Piperidinecarboxylic acid, 3-(4-broMophenyl)-, 1,1-diMethylethyl ester;1-Boc-3-(4-Bromophenyl);TERT-BUTYL 3-(4-BROMOPHENYL)PIPERIDINE-1-CARBOXYLATE 3-(4-Bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 769944-73-2
• Molecular Formula: C₁₆H₂₂BrNO₂
• Molecular Weight: 340.26
• Mol File: 769944-73-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 398.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.283
• Storage Temp.: 2-8°C
• PKA: -1.84±0.40(Predicted)
• CAS DataBase Reference: 3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester(769944-73-2)
• EPA Substance Registry System: 3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester(769944-73-2)

Safety Data

• Hazardous Substances Data: 769944-73-2(Hazardous Substances Data)

Usage

Uses

tert-?Butyl 3-?(4-?Bromophenyl)piperidine-?1-?carboxylate is an intermediate of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

Upstream product

• 129013-83-8 3-(4-bromophenyl)pyridine 
• 1692-25-7 3-pyridylboronic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 106-37-6 1.4-dibromobenzene 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 
• 148763-41-1 1-(tert-butyl) 3-methyl piperidine-1,3-dicarboxylate 
• 769944-72-1 3-(4-bromo-phenyl)-piperidine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 769944-74-3 3-(4-(4-methylpiperazin-1-yl)-phenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 769944-76-5 3-(4-cyclohexylaminophenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1338544-06-1 tert-butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate 

Relevant articles and documents

INDOLO HEPTAMYL OXIME ANALOGUE AS PARP INHIBITOR

Disclosed is a type of indolo heptamyl oxime compounds as a PARP inhibitor. Specifically disclosed are a compound as represented by formula (II) and a pharmaceutically acceptable salt thereof.

Conversion of Ester Moieties to 4-Bromophenyl Groups via Electrocyclic Reaction of Dibromocyclopropanes

(Chemical Equation Presented) Conversion of ester moieties into 4-bromophenyl groups was effected by means of a four-step protocol: a Grignard reaction of the ester with allylmagnesium halides, a ring-closing metathesis, dibromocyclopropanation, and an electrocyclic reaction of the dibromocyclopropanes.

2, 3, 6-TRISUBSTITUTED-4-PYRIMIDONE DERIVATIVES

A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof; useful for prventive and/or therapeutic treatment of diseass such as neurodegenerative diseases (e.g. Alzheimer disease); wherein Q represents CH or nitrogen atom; R represents a C1-C12 alkyl group; the ring of Formula (I): represents piperazine ring or piperidine ring; each X independently represents a C1-C8 alkyl group, an optionally partially hydrogenated C6-C10 aryl ring, an indan ring or the like; m represents an integer of 1 to 3; each Y independently represents a halogen atom, a hydroxy group, a cyano group, a C1-C6 alkyl group or the like; n represents an integer of 0 to 8; when X and Y or two Y groups are attached on the same carbon atom, they may combine to each other to form a C2-C6 alkylene group.