770-18-3

Usage

Uses

Used in Pharmaceutical Industry:
BenzeneMethanaMine, 3-fluoro-N,N-diMethylis used as a reagent in the synthesis of various drugs and medications. Its fluorinated carbon structure contributes to the development of new and effective pharmaceutical compounds.
Used in Research Laboratories:
In research settings, BenzeneMethanaMine, 3-fluoro-N,N-diMethylis employed for its potential medicinal properties. Scientists explore its applications in drug discovery and development, leveraging its unique characteristics to enhance the therapeutic effects of medications.

InChI:InChI=1/C9H12FN/c1-11(2)7-8-4-3-5-9(10)6-8/h3-6H,7H2,1-2H3

Upstream product

• 124-40-3 dimethyl amine 
• 456-42-8 m-fluorobenzyl chloride 
• 506-59-2 N,N-dimethylammonium chloride 
• 456-48-4 3-Fluorobenzaldehyde 
• 67-56-1 methanol 
• 403-54-3 m-Fluorobenzonitrile 

Downstream Products

• 675587-66-3 N,N-dimethyl-2-nitro-5-fluorobenzylamine 
• 675587-65-2 N,N-dimethyl-2,4-dinitro-5-fluorobenzylamine 
• 675587-70-9 N^α-acetyl-S-(2,4-dinitro-5-(dimethylaminomethyl)phenyl)-L-cysteine 
• 167031-65-4 Hg(C₆H₃-3-F-6-CH₂NMe₂)2 
• 1258839-94-9 ethyl 2-((dimethylamino)methyl)-4-fluorobenzoate 

Relevant academic research and scientific papers

Direct Synthesis of N,N-Dimethylated and β-Methyl N,N-Dimethylated amines from nitriles using methanol: Experimental and computational studies

Direct and selective synthesis of N,N-dimethylated amines from nitriles using methanol as C1 building blocks is reported using an air- and moisture-stable ruthenium complex. Following this process, various aromatic as well as aliphatic nitriles were converted to the corresponding N-methylated amines. Interestingly, tandem C-methylation as well as N-methylation was achieved by introducing multiple methyl groups. The practical aspect of this process was revealed by preparative-scale reactions with different nitriles and the synthesis of anti-allergic drug "avil". Several kinetic experiments and detailed DFT calculations were carried out to understand the mechanism of this process.

Cu(II)-promoted palladium-catalyzed C-H ortho-arylation of N, N-dimethylbenzylamines

A novel protocol for palladium-catalyzed arylation of the C(sp 2)-H bond directed by a N,N-dimethylaminomethyl group in the presence of AgOAc and Cu(OAc)2·H2O is described. Various aryl iodides proved to be efficient coupl

LiCl-Promoted Pd(ii)-catalyzed ortho carbonylation of N,N- dimethylbenzylamines

Palladium-catalyzed highly regioselective carbonylation of substituted N,N-dimethylbenzylamines with the assistance of LiCl was developed. The ortho-functionalized N,N-dimethylbenzylamine was further transformed into ortho-methyl benzoate under mild conditions. These two transformations could be combined into one pot to produce the desired product in moderate yield. Applications of this methodology to synthesize the fragments of variolaric acid were also studied.

Indirect ortho functionalization of substituted toluenes through ortho olefination of N,N-dimethylbenzylamines tuned by the acidity of reaction conditions

Highly regioselective olefination of substituted N,N-dimethylbenzylamines was developed by tuning the acidity of reaction conditions based on analysis of their features. The ortho-functionalized N,N-dimethylbenzylamines were further transformed into 3-(2′

Substituent effects. 14. Anomalous dissociation constants in water-organic solvent mixtures: benzylammonium ions and related systems

Thermodynamic dissociation constants in various water-organic solvent mixtures are given for benzylammonium, benzyldialkylammonium, and (2-phenylethyl)ammonium ions.Deviations from the Hammett equation (Eqn. 1) are similar to those observed for carboxylic acids, but of opposite sign.The extended Hammett equation (Eqn. 3), containing the hydrophobic constant, ?, yields good correlations.Derived secondary normal sigma values are exemplified.