770-22-9

Basic information

• Product Name: N-(3-chloro-4-fluorophenyl)formamide
• CAS NO: 770-22-9
• Molecular Formula: C₇H₅ClFNO
• Molecular Weight: 173.5721
• Mol File: 770-22-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 325.6°C at 760 mmHg
• Flash Point: 150.7°C
• Density: 1.418g/cm³
• Vapor Pressure: 0.000228mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: N-(3-chloro-4-fluorophenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chloro-4-fluorophenyl)formamide(770-22-9)
• EPA Substance Registry System: N-(3-chloro-4-fluorophenyl)formamide(770-22-9)

Safety Data

• Hazardous Substances Data: 770-22-9(Hazardous Substances Data)

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 
• 150760-95-5 formic acid cyanomethyl ester 
• 64-18-6 formic acid 
• 77287-34-4 formamide 
• 68-12-2 N,N-dimethyl-formamide 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 74702-35-5 C₆H₃ClFN(CHO)SCFCl₂ 
• 314771-88-5 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline 
• 314771-76-1 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline 
• 850140-72-6 afatinib 
• 602261-99-4 2-chloro-1-fluoro-4-isocyanobenzene 
• 77898-24-9 3-chloro-4-fluoro-N-methylaniline 

Relevant articles and documents

Design, synthesis and anticancer evaluation of 3-methyl-1H-indazole derivatives as novel selective bromodomain-containing protein 4 inhibitors

Bromodomain-containing Protein 4 (BRD4), an ‘epigenetic reader’, regulates chromatin structure and gene expression via recognizing and binding acetylated lysine in histones. BRD4 has become a therapeutic target for cancers because it promotes the expression of the tumor genes, such as c-Myc, NF-κB, and Bcl-2. In this study, a new series of 3-methyl-1H-indazole derivatives were designed via virtual screening and structure-based optimization. All compounds were synthesized and evaluated for their inhibitory activities to BRD4-BD1 and their antiproliferative effects in cancer cell lines. Among them, several compounds (such as 9d, 9u and 9w) exhibited strong BRD4-BD1 affinities and inhibition activities, and potently suppressed MV4;11 cancer cell line proliferation. Among them, compound 9d showed excellent selectivity for BRD4 and effectively suppressed c-Myc, the downstream protein of BRD4. This study provided new lead compounds for further biological evaluation on BRD4.

HCl-mediated transamidation of unactivated formamides using aromatic amines in aqueous media

We report transamidation protocol to synthesize a range of secondary and tertiary amides from weakly nucleophilic aromatic and hetero-aryl amines with low reactive formamide derivatives, utilizing hydrochloric acid as catalyst. This current acid mediated strategy is beneficial because it eliminates the need for a metal catalyst, promoter or additives in the reaction, simplifies isolation and purification. Notably, this approach conventionally used to synthesize molecules on gram scales with excellent yields and a high tolerance for functional groups.

Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction

Using the computational pharmacophore-based ANCHOR.QUERY platform a new scaffold was discovered. Potent compounds evolved inhibiting the protein-protein interaction p53-MDM2. An extensive SAR study was performed based on our four-point pharmacophore model