77012-48-7

Basic information

• Product Name: 5(4H)-Oxazolone, 4-(2-furanylmethylene)-2-phenyl-, (4Z)-
• Synonyms: 4-Furfuryliden-2-phenyl-4H-oxazol-5-on;2-Phenyl-4-furfuryliden-oxazol-5-on;4-furfurylidene-2-phenyl-4H-oxazol-5-one;2-Phenyl-4-furfuryliden-4,5-dihydro-oxazol-5-on
• CAS NO: 77012-48-7
• Molecular Formula: C14H9NO3
• Molecular Weight: 239.23
• Mol File: 77012-48-7.mol
• Article Data: 42

Chemical Properties

• CAS DataBase Reference: 5(4H)-Oxazolone, 4-(2-furanylmethylene)-2-phenyl-, (4Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(4H)-Oxazolone, 4-(2-furanylmethylene)-2-phenyl-, (4Z)-(77012-48-7)
• EPA Substance Registry System: 5(4H)-Oxazolone, 4-(2-furanylmethylene)-2-phenyl-, (4Z)-(77012-48-7)

Safety Data

• Hazardous Substances Data: 77012-48-7(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 1199-01-5 2-phenylazlactone 
• 495-69-2 Hippuric Acid 
• 89363-86-0 (Z)-2-phenyl-4-(chloromethylene)-5(4H)-oxazolone 
• 118486-94-5 2-(tributylstannyl)furan 
• 3237-23-8 N-(2-furylmethylene)aniline 
• 532-94-5 sodium hippurate 
• 108-24-7 acetic anhydride 
• 3237-22-7 2-cyano-3-(2-furanyl)acrylonitrile 
• 98-88-4 benzoyl chloride 
• 19747-03-6 2-benzoylamino-3-furan-2-yl-acryloyl azide 
• 35355-49-8 ethyl 2-azido-3-(furan-2-yl)acrylate 
• 109547-79-7 C₂₇H₂₄NO₃P 
• 19746-94-2 4-furfuryl-6-phenyl-[1,3,5]oxadiazin-2-one 

Downstream Products

• 96191-40-1 (Z)-ethyl 2-benzamido-3-(furan-2-yl)acrylate 
• 1373956-88-7 4-(furan-2-ylmethylene)-2-phenyl-1-(pyridin-4-ylmethyl)-1H-imidazol-5(4H)-one 
• 16242-12-9 4-benzoylamino-5-furan-2-yl-pyrazolidin-3-one 
• 75793-17-8 2-phenyl-5-[1-furan-2-yl-meth-(Z)-ylidene]-3,5-dihydro-imidazol-4-one 
• 1800044-94-3 (Z)-N-(1-chloro-1-(furan-2-yl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)benzamide 
• 1562376-98-0 (3R,3aS,9bR)-diethyl 3a-benzamido-3-(furan-2-yl)-4-oxo-1,3a,4,9b-tetrahydrochromeno-[4,3-b]pyrrole-2,2(3H)-dicarboxylate 
• 1314387-70-6 bis(2,2,2-trifluoroethyl) (5S,6R,9S)-6-(furan-2-yl)-4-oxo-2-phenyl-9-vinyl-3-oxa-1-azaspiro[4.4]non-1-ene-7,7-dicarboxylate 

Relevant articles and documents

Pharmaceutical composition and method of treating cancer

Cytotoxic compounds containing a phenyl core, amide link(s), an imidazolinone or a propenamide moiety. Also described are pharmaceutical compositions incorporating the cytotoxic compounds and methods for treating cancer. These compounds are cytotoxic against breast, prostate, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.

Stereoselective Intermolecular [2 + 2] Cycloadditions of Erlenmeyer-Pl?chl Azlactones Using Visible Light Photoredox Catalysis

The first report of the preparation of symmetric and nonsymmetric diaminotruxinic derivatives through the photoredox [2 + 2] cycloadditions of Erlenmeyer azlactones is described, affording the desired compounds in high regio- and diastereocontrol (only head-to-head coupling). Mechanistic studies by DFT suggest that the reaction proceeds through a neutral photocatalytic pathway.

Greener approach: Ionic liquid [Et3NH][HSO4]-catalyzed multicomponent synthesis of 4-arylidene-2-phenyl-5(4H)oxazolones under solvent-free condition

We have developed simple, greener, safer multicomponent synthesis series of 4-arylidene-2-phenyl-5(4H) oxazolones 4(a-r) catalyzed by Bronsted acid ionic liquid as triethylammonium hydrogen sulfate [Et3NH][HSO4] and catalytic amount of acetic anhydride and sodium acetate with excellent yields (90–99%). The protocol offers economical, environmentally benign, solvent-free conditions, and recycle–reuse of the catalyst and easily available starting as benzoyl chloride 1, amino acid 2 and a variety of aldehydes 3. The cyclization followed by condensation of benzoyl chloride, amino acid, and a variety of aldehydes catalyzed by ILs [Et3NH][HSO4] and catalytic amount of acetic anhydride and sodium acetate. The final products were confirmed by their characterization data such as FTIR, 1H-NMR, 13C-NMR, Mass, high-resolution mass spectra and were compared with its reported method.