117784-08-4Relevant articles and documents
One-pot process to Z-α-benzoylamino-acrylic acid methyl esters via potassium phosphate-catalyzed Erlenmeyer reaction
Cleary, Thomas,Brice, Jodie,Kennedy, Nicole,Chavez, Flavio
supporting information; experimental part, p. 625 - 628 (2010/04/05)
A practical and efficient two reaction sequence one-pot process for the synthesis of Z-α-benzoylamino-acrylic acid methyl esters was developed. The process involves a potassium phosphate-catalyzed Erlenmeyer reaction of aromatic aldehydes with hippuric acid followed by an oxazolone ring-opening methanolysis. This process afforded a good overall yield and an excellent product quality via a simple workup.
N-Acyl-α-triphenylphosphonioglycinates in the synthesis of α,β-dehydro-α-amino acid derivatives
Mazurkiewicz, Roman,Kuznik, Anna,Grymel, Miroslawa,Kuznik, Nikodem
, p. 807 - 815 (2007/10/03)
N-Acyl-α-triphenylphosphonioglycinates when treated with triethylamine are transformed to an equilibrium mixture of the corresponding N-acyliminoacetates and N-acyl-α-triphenylphosphoranylideneglycinates. Wittig reaction of the latter ylides with aromatic and aliphatic aldehydes or ketones enables a new easy entry to N-acyl-α,β-dehydro-α-amino acid esters. Springer-Verlag 2004.
On the Synthesis of 3(5)-Carbomethoxy-4-hetarylpyrazoles
Cativiela, Carlos,Villegas, Maria D. Diaz de,Mayoral, Jose A.,Avenoza, Alberto,Roy, Miguel A.
, p. 851 - 855 (2007/10/02)
3(5)-Carbomethoxy-4-hetarylpyrazoles 3 can be obtained by the aromatization of the corresponding cis-3-benzamido-3-carbomethoxy-4-hetaryl-Δ1-pyrazolines 2 obtained by 1,3-dipolar cycloaddition of diazomethane with methyl Z-2-benzamido-3-hetarylpropenoates 1.An explanation, based on FMO theory, for the different reactivity of the dipolarophiles with diazomethane is given.
