770742-65-9Relevant articles and documents
Potent inhibitors of the hepatitis C virus NS3 protease: Design and synthesis of macrocyclic substrate-based β-strand mimics
Goudreau, Nathalie,Brochu, Christian,Cameron, Dale R.,Duceppe, Jean-Simon,Faucher, Anne-Marie,Ferland, Jean-Marie,Grand-Maitre, Chantal,Poirier, Martin,Simoneau, Bruno,Tsantrizos, Youla S.
, p. 6185 - 6201 (2007/10/03)
The virally encoded NS3 protease is essential to the life cycle of the hepatitis C virus (HCV), an important human pathogen causing chronic hepatitis, cirrhosis of the liver, and hepatocellular carcinoma. The design and synthesis of 15-membered ring β-strand mimics which are capable of inhibiting the interactions between the HCV NS3 protease enzyme and its polyprotein substrate will be described. The binding interactions between a macrocyclic ligand and the enzyme were explored by NMR and molecular dynamics, and a model of the ligand/enzyme complex was developed.