77087-22-0Relevant articles and documents
A modified synthesis of (Z)-pyrethrolone
Markham, Todd E.,Duggan, Peter J.,Johnston, Martin R.
, p. 99 - 109 (2022/03/16)
An accessible, efficient, and reliable synthesis for the production of (Z)-pyrethrolone remains necessary as previous syntheses suffer from drawbacks including the use of toxic reagents, expensive starting materials and lack of regioselectivity in the production of key intermediates. This work attempts to alleviate the issues of prior syntheses by making use of well-known and regioselective transformations for the efficient synthesis of (Z)-pyrethrolone. Ultimately, (Z)-pyrethrolone is generated in an overall 20% yield over five steps from a cheap, easily accessible starting material using reliable, optimised transformations.
Method for preparing 4-hydroxy-3-methyl-2-(2-propynyl)-2-cyclopentenolone
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, (2008/06/13)
The present invention relates to a novel method for producing cyclopentenolone of the formula (I), STR1 which is a useful intermediate for producing agricultural chemicals, which comprises reacting an acetonedicarboxylic ester of the formula (VII), STR2 wherein R is a C1 -C6 alkyl group, with 2-propynyl chloride in the presence of magnesium alkoxide and in the presence of alkali iodide to obtain novel mono-(2-propynyl)-substituted acetonedicarboxylic ester of the formula (VI), STR3 wherein R is as defined above; hydrolyzing the mono-(2-propynyl)-substituted acetonedicarboxylic ester of the formula (VI) under alkaline conditions with an alkali and then reacting the hydrolyzed product with methylglyoxal of the formula, STR4 to obtain novel γ-diketone of the formula (V), STR5 and ring-closing the γ-diketone of the formula (V) under alkaline condition.
