771-26-6

Basic information

• Product Name: 4-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE
• Synonyms: 4-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE;4-Hydroxy-2,3-dihydro-4H-1,4-benzooxazine-3-one;4-Hydroxy-3,4-dihydro-2H-1,4-benzoxazine-3-one;3,4-dihydro-4-hydroxy-3-oxo-2H-1,4-benzoxazine
• CAS NO: 771-26-6
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.15
• Mol File: 771-26-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 168-169 °C(Solv: water (7732-18-5))
• Boiling Point: 329.3°C at 760 mmHg
• Flash Point: 153°C
• Appearance: /
• Density: 1.476g/cm³
• Vapor Pressure: 7.2E-05mmHg at 25°C
• Refractive Index: 1.648
• PKA: 8.04±0.20(Predicted)
• CAS DataBase Reference: 4-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE(771-26-6)
• EPA Substance Registry System: 4-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE(771-26-6)

Safety Data

• Hazardous Substances Data: 771-26-6(Hazardous Substances Data)

Usage

Uses

2-Deoxy-DIBOA is a derivative of DIBOA (D422730), an allelopathic biochemical that is produced by grasses. This benzoxazinoid compound displays health-promoting effects in rats.

InChI:InChI=1/C8H7NO3/c10-8-5-12-7-4-2-1-3-6(7)9(8)11/h1-4,11H,5H2

Upstream product

• 824-38-4 potassium 2-nitrophenoxide 
• 88-75-5 2-hydroxynitrobenzene 
• 153720-70-8 4-Allyloxy-4H-benzo[1,4]oxazin-3-one 
• 37682-31-8 ethyl o-nitrophenoxyacetate 
• 1878-87-1 2-nitrophenoxyacetic acid 
• 29603-66-5 6β-[2-(2-nitro-phenoxy)-acetylamino]-penicillanic acid 

Downstream Products

• 157067-44-2 4-benzyloxy-2H-1,4-benzoxazin-3(4H)-one 
• 33252-97-0 6-benzoyloxy-4H-benzo[1,4]oxazin-3-one 
• 53412-38-7 6-hydroxy-3,4-dihydro-2H-1,4-benzoxazin-3-one 
• 67193-97-9 7-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 5023-12-1 6-methoxy-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 17359-54-5 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one 
• 23520-34-5 Blepharigenin 
• 7652-29-1 6-chloro-2H-1,4-benzoxazin-3(4H)-one 
• 27320-99-6 3,4-dihydro-7-chloro-3-oxo-2H-1,4-benzoxazine 
• 138035-68-4 5-chloro-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 122978-10-3 N-[2,2,2-Trichloro-1-(3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yloxy)-ethyl]-benzamide 
• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 

Relevant articles and documents

Synthesis and antimicrobial activity of some benzoxazinoids derivatives of 2-nitrophenol and 3-hydroxy-2-nitropyridine

Benzoxazinoids (BXs), alkaloids frequently found in Gramineae species, are natural defensives that can potentially be exploited to the development of novel antimicrobial agents. Here, BXs analogs were synthesized from 2-nitrophenol (benzoxazinone series)

New herbicide models from benzoxazinones: Aromatic ring functionalization effects

The utility of benzoxazinones and some of their synthetic derivatives in the search for new leads for herbicide model development has been widely discussed. As the benzoxazinone skeleton contains three different potential areas for functionalization (C-2,

Structure-activity relationships (SAR) studies of benzoxazinones, their degradation products and analogues. Phytotoxicity on standard target species (STS)

Benzoxazinones 2,4-dihydroxy-7-methoxy-(2H)-1,4-benzoxazin-3(4H)-one (DIMBOA) and 2,4-dihydroxy-(2H)-1,4-benzoxazin-3(4H)-one (DIBOA) have been considered key compounds for understanding allelopathic phenomena in Gramineae crop plants such as corn (Zea mays L.), wheat (Triticum aestivum L.), and rye (Secale cereale L.). The degradation processes in the environment observed for these compounds, in which soil microbes are directly involved, could affect potential allelopathic activity of these plants. We present in this work a complete structure-activity relationships study based on the phytotoxic effects observed for DIMBOA, DIBOA, and their main degradation products, in addition to several synthetic analogues of them. Their effects were evaluated on standard target species (STS), which include Triticum aestivum L. (wheat) and Allium cepa L. (onion) as monocots and Lepidium sativum L. (cress), Lactuca sativa L. (lettuce), and Lycopersicon esculentum Will, (tomato) as dicots. This permitted us to elucidate their ecological role and to propose new herbicide models based on their structures. The best phytotoxicity results were shown by the degradation chemical 2-aminophenoxazin-3-one (APO) and several 2-deoxy derivatives of natural benzoxazinones, including 4-acetoxy-(2H)-1,4-benzoxazin- 3(4H)-one (ABOA), 4-hydroxy-(2H)-1,4-benzoxazin-3(4H)-one (D-DIBOA), and 4-hydroxy-7-methoxy-(2H)-1,4-benzoxazin-3(4H)-one (D-DIMBOA). They showed high inhibitory activity over almost all species growth. The fact that APO is a degradation product from DIBOA with high phytotoxicity and stability makes it possible to assign an important ecological role regarding plant defense mechanisms. 2-Deoxy derivatives of natural benzoxazinones display a wide range of activities that allow proposing them as new leads for natural herbicide models with a 1,4-benzoxazine skeleton.