77103-90-3Relevant academic research and scientific papers
Electroreductive acylation of aromatic ketones with acylimidazoles
Kise, Naoki,Agui, Syun,Morimoto, Shinji,Ueda, Nasuo
, p. 9407 - 9410 (2007/10/03)
The intermolecular reductive coupling of aromatic ketones with acylimidazoles was effected by electroreduction in the presence of chlorotrimethylsilane and gave α-trimethylsiloxy ketones and esters. The best result was obtained using Bu4NPF6 as a supporting electrolyte and a Pb cathode in THF. The α-trimethylsiloxy-containing products were transformed to the corresponding α-hydroxy ketones and esters by treatment with TBAF in THF. This method was also effective for the intramolecular reductive coupling of δ- and ε-keto acylimidazoles.
Hypolipidemic 4,5-Dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic Acids
Jirkovski, Ivo,Cayen, Mitchell, N.
, p. 1154 - 1156 (2007/10/02)
A series of novel 4,5-dihydro-4-oxo-5,5-disubstituted-2-furancarboxylic acids was synthesized and shown to possess potent hypotriglyceridemic activity in normal rats.In contrast to clofibrate, none of the present compounds altered liver weight at any dose
Studies on Simplified Ergoline Derivatives. A General Six-Step Synthesis of Phenyl-Substituted 4-Methyl-3,4,4a,5,6,10b-hexahydrobenzoquinolin-1-(2H)-one Analogs (1)
Salley, John J.,Glennon, Richard A.
, p. 545 - 550 (2007/10/02)
This communication outlines the development of a novel, general synthetic route to substituted α-tetralones 5, their subsequent conversion to the α,β-unsaturated ketones 11, and an improved, one-step transformation of 11 to the tricyclic title compounds 1.Thus, substituted derivatives of 1 can be prepared in six steps from simple benzaldehydes, or, in three steps from more readily available α-tetralones.
