77106-50-4Relevant academic research and scientific papers
First total synthesis of medicinally important 3,4,7-trimethoxy-9,10-dihydrophenanthrene-1,5-diol
Gangireddy Venkata, Sivarami Reddy,Narkhede, Umesh C.,Jadhav, Vinod D.,Gangu Naidu, Ch.
, p. 1670 - 1673 (2018/03/29)
The first total synthesis was successfully achieved for biologically active 9,10-dihydrophenanthrene-1,5-diol. The key features of our synthetic approach are Perkin condensation, followed by bromination, palladium mediated intramolecular C-C bond coupling, and selective isopropyl ether cleavage. Synthesized compounds were purified and characterized by IR, 1HNMR, 13CNMR and HRMS/LC-MS.
Synthesis of Lamellarin G Trimethyl Ether by von Miller–Pl?chl-Type Cyclocondensation
Colligs, Vanessa C.,Dialer, Clemens,Opatz, Till
, p. 4064 - 4070 (2018/07/31)
A concise synthesis of lamellarin G trimethyl ether based on a von Miller–Pl?chl-type cyclocondensation of a deprotonated α-amino nitrile with an α,β-unsaturated ketone as the key step was developed. The general strategy does not rely on molecular symmetry and allows for the independent variation of the substitution pattern.
