Benzene, 1,2-dimethoxy-4-(1-methylethoxy)-

Base Information

• Chemical Name: Benzene, 1,2-dimethoxy-4-(1-methylethoxy)-
• CAS No.: 77106-50-4
• Molecular Formula: C11H16 O3
• Molecular Weight: 196.246
• Hs Code.: 2909309090
• Mol file: 77106-50-4.mol

Synonyms:3,4-Dimethoxy-1-isopropoxybenzene

Chemical Property of Benzene, 1,2-dimethoxy-4-(1-methylethoxy)-

Chemical Property:

• Vapor Pressure: 0.0127mmHg at 25°C
• Boiling Point: 268.4°C at 760 mmHg
• Flash Point: 88.5°C
• PSA: 27.69000
• Density: 1.007g/cm³
• LogP: 2.49100

Purity/Quality:

99% ^*data from raw suppliers

4-Isopropoxy-1,2-dimethoxybenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 1,2-dimethoxy-4-(1-methylethoxy)-

There total 4 articles about Benzene, 1,2-dimethoxy-4-(1-methylethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3,4-dimethoxyphenol (2033-89-8) + isopropyl bromide (75-26-3) → 1,2-dimethoxy-4-(propan-2-yloxy)benzene (77106-50-4)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 94h;

DOI:10.1002/ejoc.201800611

Reference yield: 82.0%

2-iodo-propane (75-30-9) + 3,4-dimethoxyphenol (2033-89-8) → 1,2-dimethoxy-4-(propan-2-yloxy)benzene (77106-50-4)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃; for 24h;

DOI:10.1016/j.tetlet.2018.03.049

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → 1,2-dimethoxy-4-(propan-2-yloxy)benzene (77106-50-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

2: potassium carbonate / methanol / 1 h / 20 °C

3: potassium carbonate / acetonitrile / 24 h / 60 °C

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.tetlet.2018.03.049

upstream raw materials:

3,4-dimethoxyphenol

isopropyl bromide

3,4-dimethoxy-benzaldehyde

2-iodo-propane

Downstream raw materials:

14-(3,4-dimethoxyphenyl)-2,3,11,12-tetramethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

2',5,7-triisopropyloxy-4',5',6-trimethoxyflavone

2'-hydroxy-2,4',6'-triisopropyloxy-4,5,5'-trimethoxychalcone

2',5,7-trihydroxy-4',5',6-trimethoxyflavone

Refernces

• 1、 Gangireddy Venkata, Sivarami Reddy,Narkhede, Umesh C.,Jadhav, Vinod D.,Gangu Naidu, Ch.. "First total synthesis of medicinally important 3,4,7-trimethoxy-9,10-dihydrophenanthrene-1,5-diol". . p. 1670 - 1673. Retrieved 2018/03/29.