77112-27-7

Upstream product

• 108-42-9 3-chloro-aniline 
• 7148-74-5 2-Bromopropionyl chloride 
• 563-76-8 α-bromopropionyl bromide 

Downstream Products

• 1400272-64-1 N-(3-chlorophenyl)-2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)propionamide 
• 349579-42-6 C₁₅H₁₄ClNO₂ 
• 51940-81-9 1-(3-chloro-phenyl)-3-[2-(3,3-dipropyl-azetidin-1-yl)-1-methyl-ethyl]-4-methyl-imidazolidin-2-one 
• 51940-84-2 1-(3-chloro-phenyl)-3-[2-(3,3-dimethyl-azetidin-1-yl)-1-methyl-ethyl]-4-methyl-imidazolidin-2-one 
• 77112-29-9 3-(3-chlorophenyl)-1-<(2-dimethylamino)-1-methylethyl>-5-methyl-2-imidazolidinone hydrochloride 
• 51940-93-3 3-(3-chlorophenyl)-1-(2-hydroxy-1-methylethyl)-5-methyl-2-imidazolidinone 
• 51940-82-0 1-(2-chloro-1-methylethyl)-3-(3-chlorophenyl)-5-methyl-2-imidazolidinone 
• 51940-90-0 2-<2-(3-chlorophenylamino)-1-methylethylamino>-1-propanol 
• 84970-21-8 N-(3-chloro-phenyl)-2-morpholin-4-yl-propionamide 

Relevant academic research and scientific papers

Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists

Herein we describe the development of a focused series of functionalized pyridazin-3(2H)-one-based formyl peptide receptor (FPR) agonists that demonstrate high potency and biased agonism. The compounds described demonstrated biased activation of prosurvival signaling, ERK1/2 phosphorylation, through diminution of the detrimental FPR1/2-mediated intracellular calcium (Cai2+) mobilization. Compound 50 showed an EC50 of 0.083 μM for phosphorylation of ERK1/2 and an approximate 20-fold bias away from Cai2+ mobilization at the hFPR1.

Copper-Catalyzed Cross-Coupling of Secondary α-Haloamides with Terminal Alkynes: Access to Diverse 2,3-Allenamides

A copper-catalyzed C(sp)?C(sp3) cross-coupling of terminal alkynes with readily available secondary α-haloamides for the efficient synthesis of 2,3-allenamides is realized. The methodology is characterized by its wide substrate scope, which makes it an important complement to traditional methods for synthesizing allenes. A mechanism involving an alkynylcopper species is proposed. (Figure presented.).

Direct amination of phenols under metal-free conditions

Herein, we disclose the metal-free synthesis of arylamines via the direct amination of phenols using aminating reagents. This reaction procedure uses easy accessible aminating reagents and provides a versatile synthetic route to a broad range of arylamines with various functionalities in good to excellent yield. By using a two-step route of amination and oxidative coupling reaction, we synthesized three naturally occurring carbazole alkaloids: murrayafoline A, mukonine, and clausenine from two commercially available phenols. Georg Thieme Verlag Stuttgart · New York.

Design and synthesis of new 8-anilide theophylline derivatives as bronchodilators and antibacterial agents

Theophylline derivatives have long been recognized as potent bronchodilators for the relief of acute asthma. Recently, it was found that bacterial infection has a role in asthma pathogenesis. The present work involves the design and synthesis of 8-substituted theophylline derivatives as bronchodilators and antibacterial agents. The chemical structures of these compounds were elucidated by IR, 1H-NMR, mass spectrometry, and elemental analyses. The bronchodilator activity was evaluated using acetylcholine-induced bronchospasm in guinea pigs, and most of the compounds showed significant anti-bronchoconstrictive activity in comparison with standard aminophylline. In addition, the antibacterial activity of all the target compounds was investigated in vitro against Gram-positive and Gram-negative bacteria using ampicillin as a reference drug. Results showed that some of the tested compounds possessed significant antibacterial activity. A pharmacophore model was computed to obtain useful insight into the essential structural features of bronchodilator activity. A structure activity relationship was also discussed.