1250999-20-2

Basic information

• Product Name: 2-Bromo-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester
• Synonyms: 2-Bromo-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester;2-Bromo-5,6-Dihydro-8H-Imidazo[1,2-A]Pyrazine-7-Carboxylic Acid Tert-Butyl Ester(WX140588)
• CAS NO: 1250999-20-2
• Molecular Formula: C11H16BrN3O2
• Molecular Weight: 302.16764
• Mol File: 1250999-20-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 432.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.52±0.1 g/cm3(Predicted)
• PKA: 4.62±0.20(Predicted)
• CAS DataBase Reference: 2-Bromo-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester(1250999-20-2)
• EPA Substance Registry System: 2-Bromo-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester(1250999-20-2)

Safety Data

• Hazardous Substances Data: 1250999-20-2(Hazardous Substances Data)

Usage

General Description

2-Bromo-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester is a chemical compound with the molecular formula C13H15BrN4O2. It is used in the pharmaceutical industry for the synthesis of various drug molecules. 2-Bromo-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid tert-butyl ester is a tert-butyl ester derivative of imidazopyrazine carboxylic acid, and its structure includes a bromide substituent and a tert-butyl ester group. It is a white to off-white solid that is soluble in organic solvents and can be used as a reagent in organic synthesis. It has potential biological activity and has been studied for its antimicrobial, antiparasitic, and antitumor effects.

Upstream product

• 1289267-53-3 imidazo[1,2-a]pyrazin-2-amine 
• 77112-53-9 imidazo <1,2-a>pyrazine-2-carboxylic acid 
• 77112-52-8 ethyl imidazo[1,2-a]pyrazine-2-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1613148-22-3 2,3-dibromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 

Downstream Products

• 1613148-23-4 (R)-N,N-bis(tert-butoxycarbonyl)-5-(7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-yl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 
• 1613148-21-2 3-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-2-yl)pyridin-2-amine 

Relevant articles and documents

Substituted ring compound and its method and use thereof

The invention provides a substituted cyclic compound as well as a use method and application thereof. The compound is a compound as shown in a formula (I) or stereoisomers, stereomers, tautomers, nitric oxides, solvates, metabolites and pharmaceutically acceptable salts or prodrugs of the compound as shown in the formula (I). The invention further provides a medicament composition containing the compound. The compound and the medicament composition are capable of regulating the activity of protein kinase in a biological sample body and are used for protecting, treating or relieving proliferative diseases of patients. The formula (I) is as shown in the specification.

SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted alkynyl compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.