77112-53-9

Usage

Uses

Used in Pharmaceutical Industry:
IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID is used as a key building block for the synthesis of various drugs, particularly for the development of antiviral and antibacterial agents. Its unique structure allows for the creation of compounds with targeted therapeutic effects.
Used in Academic Research:
In the field of academic research, IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID serves as a crucial component in the development of new medicinal compounds. Researchers leverage its properties to explore and innovate potential treatments for various diseases and conditions.
Used in Drug Production:
As a valuable intermediate, IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID is integral to the manufacturing process of a variety of pharmaceuticals. Its presence in the synthesis chain ensures the production of effective and safe medications for patient use.

InChI:InChI=1/C7H5N3O2/c11-7(12)5-4-10-2-1-8-3-6(10)9-5/h1-4H,(H,11,12)

Upstream product

• 77112-52-8 ethyl imidazo[1,2-a]pyrazine-2-carboxylate 
• 5049-61-6 2-Aminopyrazine 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 77112-52-8 ethyl imidazo[1,2-a]pyrazine-2-carboxylate 
• 623564-18-1 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester hydrochloride 
• 1227685-81-5 C₂₅H₂₆F₂N₈O₅ 
• 1250999-20-2 2-bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 

Relevant academic research and scientific papers

Green Synthesis and Antimicrobial Activity of Some Novel N-Arylimidazo[1,2-a]pyrazine-2-Carboxamide Derivatives

The article deals with the synthesis of some novel N-arylimidazo[1,2-a]pyrazine-2-carboxamides (7a-l) by condensation reaction of imidazo[1,2-a]pyrazine-2-carboxylic acid (5) with different aliphatic/aromatic amines (6a-l) by using 1-methylimidazole, Mukaiyama’s reagent and 2-chloro-1-methylpyridinium iodide under microwave irradiation conditions. A new series of compounds 7 have been prepared from 2-iodopyrazine (1). Compound 1 on purged with ammonia gas in the presence of Cu2O and K2CO3 furnishes pyrazin-2-amine (2), which is treated with ethyl 3-bromo-2-oxopropanoate (3) to produce ethyl imidazo[1,2-a]pyrazine-2-carboxylate (4), which on hydrolysis with NaOH yields imidazo[1,2-a]pyrazine-2-carboxylic acid (5). The structures of the newly synthesized compounds have been elucidated on the basis of spectral (IR, 1H and 13C NMR and MS) and analytical data. Compounds 7a-l have also been screened for their antimicrobial activity. Some of the compounds exhibit promising antimicrobial activity.

Three nitrogen antifungal compound, its pharmaceutical composition and its preparation and use

The present invention provides triazole compounds expressed by a general formula (I), and optical isomers or pharmaceutically acceptable salts thereof; and application of the compounds, and the optical isomers or pharmaceutically acceptable salts thereof

SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties

A series of imidazo[1,2-a]pyrazine derivatives was synthesized by condensation of α-halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo[1,2-a]pyrazine showed positive chronotropic and inotropic properties; the latter was associated with an increase in the cyclic AMP tissue concentration. Potentiation of the isoproterenol positive inotropic effect of 5-bromoimidazo[1,2-a]pyrazine and the lack of blockade of the 5-bromoimidazo[1,2-a]pyrazine positive inotropic effect by propranolol suggested phosphodiesterase-inhibiting properties.