77123-24-1 Usage
Description
(7R,8S,8aR,9aS)-7,8,8a,9a-tetrahydrochryseno[3,4-b]oxirene-7,8-diol is a complex chemical compound that features a unique four-ring system, a bridged oxirene ring, and two hydroxyl groups. As a chryseno derivative, it is a stereoisomer with specific configurations at the 7R, 8S, 8aR, and 9aS positions. (7R,8S,8aR,9aS)-7,8,8a,9a-tetrahydrochryseno[3,4-b]oxirene-7,8-diol is not naturally occurring and must be synthesized in a laboratory setting. Its potential applications in organic chemistry research and pharmaceutical development are of interest, but further investigation is necessary to fully comprehend its properties and possible uses.
Uses
Used in Organic Chemistry Research:
(7R,8S,8aR,9aS)-7,8,8a,9a-tetrahydrochryseno[3,4-b]oxirene-7,8-diol is used as a research compound for exploring its chemical properties and reactivity within various organic reactions. Its unique structure may provide insights into new reaction mechanisms and synthetic pathways.
Used in Pharmaceutical Development:
As a chryseno derivative, (7R,8S,8aR,9aS)-7,8,8a,9a-tetrahydrochryseno[3,4-b]oxirene-7,8-diol may be utilized as a starting material or a structural component in the development of new pharmaceuticals. Its specific stereochemistry could be crucial for the compound's biological activity, making it a valuable candidate for drug design and optimization.
Used in Material Science:
(7R,8S,8aR,9aS)-7,8,8a,9a-tetrahydrochryseno[3,4-b]oxirene-7,8-diol's structural features may also find applications in material science, where its unique properties could be harnessed to create novel materials with specific characteristics, such as improved stability or reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 77123-24-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,1,2 and 3 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 77123-24:
(7*7)+(6*7)+(5*1)+(4*2)+(3*3)+(2*2)+(1*4)=121
121 % 10 = 1
So 77123-24-1 is a valid CAS Registry Number.
77123-24-1Relevant articles and documents
Synthesis of the Dihydrodiol and Diol Epoxide Metabolites of Chrysene and 5-Methylchrysene
Harvey, Ronald G.,Pataki, John,Lee, Hongmee
, p. 1407 - 1412 (2007/10/02)
Carcinogenic polycyclic aromatic hydrocarbons are known to undergo enzymatic activation to diol epoxide metabolites bearing an epoxide ring in a bay molecular region.Introduction of a methyl group into a nonbenzo bay region position generally enhances carcinogenic activity.We now report efficient syntheses of the diasteromeric anti and syn bay region diol epoxide derivatives of both chrysene and 5-methylchrysene (5-MC) in both bay regions.The anti- and syn-1,2-diol-3,4-epoxide derivatives of 5-MC (1b and 2b) are the first examples of synthetic diol epoxides with a methyl group in the same bay region as the epoxide ring.NMR analysis indicates that these diol epoxide derivatives and the related dihydrodiols, with the exception of 2b and the syn-7,8-diol-9,10-epoxide of 5-methylchrysene (2c), exist preferentially in the diequational conformation in solution; 2b and 2c show a slight predominance of the diaxial conformer.All the synthetic diol epoxides were sufficiently stable to conduct biological experiments on tumorigenicity and DNA binding on mouse skin; the results confirm that 1b is the major active carcinogenic form of 5-methylchrysene which binds covalently to DNA in vivo.
