77129-49-8

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Dihydroxy-4-methoxychalcone is used as a therapeutic agent for its antioxidant, anti-inflammatory, and anti-cancer properties. It has the potential to treat various diseases and conditions, including cancer, diabetes, and metabolic disorders.
Used in Antioxidant Applications:
2,6-Dihydroxy-4-methoxychalcone is used as an antioxidant to protect cells from oxidative stress and damage, which can contribute to the prevention and treatment of various diseases.
Used in Anti-inflammatory Applications:
2,6-Dihydroxy-4-methoxychalcone is used as an anti-inflammatory agent to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
Used in Anticancer Applications:
2,6-Dihydroxy-4-methoxychalcone is used as an anticancer agent to inhibit the growth and proliferation of cancer cells, potentially leading to the development of novel cancer therapies.
Used in Metabolic Disorders Treatment:
2,6-Dihydroxy-4-methoxychalcone is used as a treatment for diabetes and other metabolic disorders, potentially improving insulin sensitivity and glucose metabolism.
Used in Antimicrobial Applications:
2,6-Dihydroxy-4-methoxychalcone is used as an antimicrobial agent against various pathogens, demonstrating its potential as a natural alternative to conventional antibiotics in the treatment of infections.

Upstream product

• 2174-64-3 5-methoxyresorcinol 
• 102-92-1 cinnamoyl chloride 
• 892871-94-2 C₁₉H₂₀O₄ 
• 7507-89-3 2,6-dihydroxy-4-methoxy-acetophenone 

Downstream Products

• 520-28-5 tectochrysine 
• 943896-07-9 (+)-hostmanin A 
• 35241-55-5 1-(2,6-dihydroxy-4-methoxy-phenyl)-3-phenyl-propan-1-one 

Relevant academic research and scientific papers

A novel one-pot synthesis of flavones

In this paper, a one-pot facile route for the BiCl3/RuCl3-mediated synthesis of functionalized flavones is described, including: (i) intermolecularortho-acylation of substituted phenols with cinnamoyl chlorides, and (ii) intramolecular cyclodehydrogenation of the resultingo-hydroxychalcones. The reaction conditions are discussed herein.

Pro-angiogenic effects of chalcone derivatives in zebrafish embryos in vivo

The aim of this study was to investigate novel chalcones with potent angiogenic activities in vivo. Chalcone-based derivatives were evaluated using a transgenic zebrafish line with fluorescent vessels to real-time monitor the effect on angiogenesis. Results showed that the chalcone analogues did not possess anti-angiogenic effect on zebrafish vasculatures; instead, some of them displayed potent pro-angiogenic effects on the formation of the sub-intestinal vein. Similar pro-angiogenic effects can also be seen on wild type zebrafish embryos. Moreover, the expression of vegfa, the major regulator for angiogenesis, was also upregulated in their treatment. Taken together, we have synthesized and identified a series of novel chalcone-based derivatives as potent in vivo pro-angiogenic compounds. These novel compounds hold potential for therapeutic angiogenesis.

Evaluation of the anti-inflammatory effect of chalcone and chalcone analogues in a Zebrafish model

The aim of this study was to investigate novel chalcones with potent anti-inflammatory activities in vivo. Chalcone and two chalcone analogues (compound 5 and 9) were evaluated using a caudal fin-wounded transgenic zebrafish line Tg(mpx:gfp) to visualize the effect of neutrophil recruitment dynamically. Results showed that treatment with compound 9 not only affected wound-induced neutrophil recruitment, but also affected Mpx enzymatic activity. Moreover, protein expression levels of pro-inflammatory factors (Mpx, NFκB, and TNFα) were also regulated by compound 9. Taken together, our results provide in vivo evidence of the anti-inflammatory effects of synthesized chalcone analogues on wound-induced inflammation.

Electron transfer-initiated Diels-Alder cycloadditions of 2′-hydroxychalcones

An efficient approach to cyclohexenyl chalcones employing highly electron rich 2′-hydroxychalcone dienophiles via electron transfer-initiated Diels-Alder cycloaddition is described. Using the methodology, the total synthesis of nicolaiodesin C has been accomplished. Copyright