77133-43-8

Upstream product

• 46049-49-4 (S)-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanamine 
• 24251-50-1 2-(2,6-dimethoxyphenoxy)ethyl chloride 
• 120723-92-4 (2R)-2-(iodomethyl)-1,4-benzodioxane 
• 40515-98-8 2-(2,6-dimethoxyphenoxy)ethylamine 
• 533-58-4 2-Iodophenol 
• 98572-00-0 (S)-2-hydroxymethyl-1,4-benzodioxane 
• 187543-59-5 (R)-7-methyl-1,4-benzodioxan-2-ylmethyl 4-toluenesulphonate 
• 62501-68-2 (2S)-3-(2'-benzyloxyphenoxy)-1,2-propanediol ditosylate 
• 62501-69-3 (2S)-3-(2'-hydroxyphenoxy)-1,2-propanediol ditosylate 
• 62501-67-1 (2R)-3-(2'-benzyloxyphenoxy)-1,2-propanediol 
• 71084-45-2 (S)-2-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)isoindoline-1,3-dione 
• 62501-70-6 (R)-(2,3-dihydrobenzo[b][1,4] dioxin-2-yl)methyl 4-methylbenzenesulfonate 
• 62501-66-0 (2S)-3-(2'-benzyloxyphenoxy)-1,2-propanediol acetonide 

Relevant academic research and scientific papers

Method for synthesizing asymmetric C-O coupled compound and application of asymmetric C-O coupled compound

The invention discloses a method for synthesizing an asymmetric C-O coupled compound and application of the asymmetric C-O coupled compound and belongs to the technical field of chemical synthesis. According to the method, a compound represented by a form

Molecular properties of the WB4101 enantiomers and of its chiral methyl derivatives for α1-adrenoceptor recognition

The optical isomers of the well known α1-antagonist WB4101 and of its derivatives with a methyl group in the oxyethyl moiety were prepared for the evaluation of their α-adrenoceptors binding affinity. By means of a detailed computational analysis, the present work shows that the introduction of a methyl group affects the behaviour of WB4101 in different ways. A limitation of the conformational freedom in certain regions of the torsional subspace of the potential energy function, differences in the reactivity of the protonated species towards a model proton acceptor and the quality of the superposition with the rigid template for α1 antagonists, corynanthine, are examined and discussed in order to select a candidate bioactive form and possible features which act as modulators of the recognition process at the α1-adrenoceptors.