62501-70-6

Basic information

• Product Name: 1,4-Benzodioxin-2-methanol, 2,3-dihydro-, 4-methylbenzenesulfonate, (R)-
• CAS NO: 62501-70-6
• Molecular Formula: C16H16O5S
• Molecular Weight: 320.366
• Mol File: 62501-70-6.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 1,4-Benzodioxin-2-methanol, 2,3-dihydro-, 4-methylbenzenesulfonate, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Benzodioxin-2-methanol, 2,3-dihydro-, 4-methylbenzenesulfonate, (R)-(62501-70-6)
• EPA Substance Registry System: 1,4-Benzodioxin-2-methanol, 2,3-dihydro-, 4-methylbenzenesulfonate, (R)-(62501-70-6)

Safety Data

• Hazardous Substances Data: 62501-70-6(Hazardous Substances Data)

Usage

Type of Compound

Pharmaceutical intermediate

Structural Motif

1,4-Benzodioxin

Optical Activity

(R)enantiomer

Stereochemistry

Optically active

Synthesis

Synthesized from the corresponding (S)-enantiomer

Applications

Production of various medications and fine chemicals

Importance

Crucial for the synthesis of certain pharmaceutical compounds due to its specific stereochemical properties

Natural Occurrence

Found in a variety of natural and synthetic compounds

Solubility

Not mentioned in the material provided

Stability

Not mentioned in the material provided

Reactivity

Not mentioned in the material provided

Toxicity

Not mentioned in the material provided

Physical State

Not mentioned in the material provided

Molecular Weight

Not mentioned in the material provided

Appearance

Not mentioned in the material provided

Melting Point

Not mentioned in the material provided

Boiling Point

Not mentioned in the material provided

Density

Not mentioned in the material provided

Upstream product

• 62501-69-3 (2S)-3-(2'-hydroxyphenoxy)-1,2-propanediol ditosylate 
• 113826-06-5 (R)-glycidyl tosylate 
• 120-80-9 benzene-1,2-diol 
• 98-59-9 p-toluenesulfonyl chloride 
• 533-58-4 2-Iodophenol 
• 3663-79-4 methyl 2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate 
• 81703-47-1 (2S,1'R)-2-oxiranyl-1,4-benzodioxan 
• 62501-68-2 (2S)-3-(2'-benzyloxyphenoxy)-1,2-propanediol ditosylate 
• 62501-67-1 (2R)-3-(2'-benzyloxyphenoxy)-1,2-propanediol 
• 62501-66-0 (2S)-3-(2'-benzyloxyphenoxy)-1,2-propanediol acetonide 
• 98572-00-0 (S)-2-hydroxymethyl-1,4-benzodioxane 
• 62501-72-8 (R)-2-hydroxymethyl-1,4-benzodioxane 
• 1106940-62-8 1-(5-fluoro-2-((R)-2-oxiranylmethoxy)phenyl)ethanone 
• 115563-62-7 (S)-1,4-benzodioxane-2-carboxaldehyde 

Downstream Products

• 115649-79-1 (+)-Spiroxatrine 
• 1106939-57-4 1-((S)-1-(2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl)-3-(2-methoxyphenyl)pyrrolidine 
• 77133-43-8 (S)-WB-4101 
• 46049-49-4 (S)-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanamine 

Relevant articles and documents

DOPAMINE D2 RECEPTOR LIGANDS

The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity. The present invention relates to novel compounds that modulate dopamine D2 receptors. In particular, compounds of the present invention show functional selectivity at the dopamine D2 receptors and exhibit selectivity downstream of the D2 receptors, on the 0- arrestin pathway and/or on the cAMP pathway.

Orally active ghrelin receptor inverse agonists and their actions on a rat obesity model

A series of 2-alkylamino nicotinamide analogs was prepared as orally active ghrelin receptor (ghrelinR) inverse agonists. Starting from compound 1, oral bioavailability was improved by modifying metabolically unstable sites and reducing molecular weight. Brain-permeable compound 33 and compound 24 with low brain permeability were tested in rat models of obesity; 30 mg/kg of compound 33 suppressed weight gain. PK/PD analysis revealed that the anti-obesity effect of ghrelinR inverse agonists depends on their brain concentrations.