77134-74-8

Basic information

• Product Name: [4-(HYDROXYMETHYL)-1-TRITYL-1H-IMIDAZOL-5-YL]METHANOL
• Synonyms: [4-(HYDROXYMETHYL)-1-TRITYL-1H-IMIDAZOL-5-YL]METHANOL;4,5-dihydroxyMethyl-1-triphenylMethyliMidazole;4,5-Bis(hydroxyMethyl)-1-trityliMidazole, 97%;1-(Triphenylmethyl)-1H-imidazole-4,5-dimethanol
• CAS NO: 77134-74-8
• Molecular Formula: C₂₄H₂₂N₂O₂
• Molecular Weight: 370.44
• Mol File: 77134-74-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 192-193℃
• Boiling Point: 572.3ºC at 760 mmHg
• Flash Point: 299.9ºC
• Appearance: /Solid
• Density: 1.15g/cm3
• Vapor Pressure: 6.15E-14mmHg at 25°C
• Refractive Index: 1.618
• CAS DataBase Reference: [4-(HYDROXYMETHYL)-1-TRITYL-1H-IMIDAZOL-5-YL]METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(HYDROXYMETHYL)-1-TRITYL-1H-IMIDAZOL-5-YL]METHANOL(77134-74-8)
• EPA Substance Registry System: [4-(HYDROXYMETHYL)-1-TRITYL-1H-IMIDAZOL-5-YL]METHANOL(77134-74-8)

Safety Data

• Hazardous Substances Data: 77134-74-8(Hazardous Substances Data)

Usage

General Description

[4-(HYDROXYMETHYL)-1-TRITYL-1H-IMIDAZOL-5-YL]METHANOL is a chemical compound with the molecular formula C26H25N2O2. It is a derivative of imidazole and contains a trityl group. The trityl group is a protecting group often used in organic synthesis to temporarily mask reactive functional groups. The compound also contains a hydroxymethyl group, which is a functional group consisting of a hydroxyl group (-OH) bonded to a methyl group (-CH3). [4-(HYDROXYMETHYL)-1-TRITYL-1H-IMIDAZOL-5-YL]METHANOL is likely to have applications in organic synthesis and could potentially be used in the development of pharmaceuticals or other specialty chemicals.

InChI:InChI=1/C24H22N2O2/c27-16-22-23(17-28)26(18-25-22)24(19-10-4-1-5-11-19,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-15,18,27-28H,16-17H2

Upstream product

• 76-83-5 trityl chloride 
• 3304-70-9 dimethyl imidazole-4,5-dicarboxylate 
• 77134-73-7 dimethyl 1-triphenylmethylimidazole-4,5-dicarboxylate 

Downstream Products

• 82032-46-0 4-acetoxymethyl-5-hydroxymethyl-1-triphenylmethylimidazole 
• 82032-55-1 (E)-3-(5-Hydroxymethyl-1-trityl-1H-imidazol-4-yl)-acrylonitrile 
• 82032-56-2 (Z)-3-(5-Hydroxymethyl-1-trityl-1H-imidazol-4-yl)-acrylonitrile 
• 82032-51-7 4-cyano-5-hydroxymethyl-1-triphenylmethylimidazole 
• 77134-75-9 5-hydroxymethyl-4-trimethylacetoxymethyl-1-triphenylmethylimidazole 
• 82032-50-6 5-(4-hydroxymethyl-1-triphenylmethyl)imidazolecarboxaldehyde 
• 82032-49-3 4-(5-hydroxymethyl-1-triphenylmethyl)imidazolecarboxaldehyde 
• 33457-48-6 4,5-dihydroxymethylimidazole 
• 76-84-6 triphenylmethyl alcohol 

Relevant articles and documents

Synthesis and antiproliferatory activity of ruthenium complexes containing N-heterocyclic carboxylates

Solvates of the complexes Ru2Cl(pic)4(EtOH) (2), Ru(Im-CO2)3 (3), and Ru(Im-CO2)(Im-CO2H)Cl2 (4), were synthesized from reaction of RuCl3·3H2O or K3[RuCl6] with the N-heterocyclic carboxylic acids pyridine-2-carboxylic acid (picolinic acid, Hpic), and imidazole-4-carboxylic acid (Im-CO2H). Crystals of 2–4 could not be grown and hence characterization was done by elemental analysis, NMR, IR, and conductivity data; 2 and 4 were tested for antiproliferatory activity in vitro against a human breast cancer cell line, but were less active than, for example, Ru complexes containing bis-imidazole or 4,4′-biimidazole that we studied previously [see Can. J. Chem. 89 (2011) 948]. Preliminary work with a third potential ligand, 3-nitro-1,2,4-triazole-5-carboxylic acid (abbreviated HCANT), and other nitro heterocyclic compounds is also presented.