77144-22-0

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 115-18-4 2-methyl-3-buten-2-ol 
• 24509-88-4 2-methyl-3-buten-2-yl acetate 
• 696-62-8 para-iodoanisole 
• 3179-10-0 (E)-1-methoxy-4-(2-nitrovinyl)benzene 
• 67-63-0 isopropyl alcohol 
• 123-11-5 4-methoxy-benzaldehyde 
• 107902-17-0 3-Benzenesulfinyl-3-chloro-4-(4-methoxy-phenyl)-2-methyl-butan-2-ol 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 24393-56-4 ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate 
• 74-88-4 methyl iodide 
• 3901-07-3 3-(4-methoxy-phenyl)acrylic acid methyl ester 

Downstream Products

• 17598-02-6 2,2 dimethyl 7 methoxychromene 
• 96307-90-3 C₁₂H₁₅O⁽¹⁺⁾ 
• 20110-12-7 2E,4E-5-(4-methoxyphenyl)-3-methyl-2,4-pentadienoic acid 

Relevant academic research and scientific papers

Copper-Catalyzed Alkenylation of Alcohols with β-Nitrostyrenes via a Radical Addition-Elimination Process

A new method for the preparation of allylic alcohol derivatives has been developed via a radical mechanism using DTBP as the radical initiator promoted by copper salt. The C(sp3)-H bond in various alcohols, toluene derivatives, and alkanes were successfully converted into C-C bonds to yield the desired products in moderate to good yields.

Palladium-catalyzed selective Heck-type diarylation of allylic esters with aryl halides involving a β-OAc elimination process

Palladium-catalyzed selective Heck-type diarylation of allylic esters with aryl halides has been developed. Allylic esters are reacted with aryl iodides to provide the corresponding 1,3-diaryl propenes through a β-OAc elimination process. It is noteworthy that the methodology can be applied in constructing the indole and benzofuran skeletons.(Figure Presented)

New and efficient synthesis of solid-supported organotin reagents and their use in organic synthesis

Novel resin-bound organotin reagents have been prepared, including for the first time resin-bound dimethyl tin reagents. Mild methodology has also been developed for the very efficient synthesis of resin-bound distannanes. The resin-bound tin chloride rea

Stille reactions catalytic in tin: A "Sn-F" route for intermolecular and intramolecular couplings

(Chemical Equation Presented) Polymethylhydrosiloxane (PMHS) made hypercoordinate by KF(aq) allows Me3SnH to be recycled during a Pd(0)-catalyzed hydrostannation/Stille cascade. Starting with a variety of alkynes, in situ vinyltin formation is followed by Stille reaction with aryl, styryl, benzyl, or vinyl electrophiles present in the reaction mixture. Both inter- and intramolecular versions of the process are possible with tin loads of approximately 6 mol %. Regeneration of the organotin hydride is believed to proceed through a Me3SnF intermediate. Given the aggregated nature of organotin fluorides and the ability to use these organotins in substoichiometric quantities, the hazards and purification problems associated with the removal of organotin wastes from reaction mixtures are minimized.

Heck reactions of aryl bromides with alk-1-en-3-ol derivatives catalysed by a tetraphosphine/palladium complex

cis,cis,cis-1,2,3,4-Tetrakis(diphenylphosphinomethyl)cyclopentane/ [PdCl(C3H5)]2 efficiently catalyses the Heck reaction of alk-1-en-3-ol with a variety of aryl bromides. In the presence of hex-1-en-3-ol or oct-1-en-3-ol, the β-arylated carbonyl compounds were selectively obtained. Linalool and 2-methylbut-3-en-2-ol led to the corresponding 1-arylalk-1-en-3-ol derivatives. Turnover numbers up to 69,000 can be obtained for this reaction. A minor electronic effect of the substituents of the aryl bromide was observed. Similar reaction rates were observed in the presence of activated aryl bromides such as bromoacetophenone and deactivated aryl bromides such as bromoanisole.

Stille couplings catalytic in tin: a "Sn-F" approach.

A new tin recycling method for Stille couplings catalytic in tin is reported. PMHS made hypercoordinate by KF((aq)) allows Me(3)SnH to be efficiently recycled during a Pd(0)-catalyzed hydrostannation/Stille cascade. Relative to previously disclosed protoc

STEREOSELECTIVE SYNTHESIS OF 5-ARYL-3-METHYL-2E,4E-PENTADIENALS

A series of 5-aryl-3-methyl-2E,4E-pentadienals were synthesized stereoselectively from 4-aryl-3E-buten-2-ones and methylmagnesium iodide followed by formylation of the obtained tertiary dimethylstyrylcarbinols by the formylating complex produced from dimethylformamide and phosphorus oxychloride.A synthesis of 2,3,6-trimethyl-4-methoxybenzaldehyde, starting from pseudocumene, is proposed.

Stereospecific Desulfinylation of α,β-Epoxy Sulfoxides with Butyllithium. A New Synthesis of Epoxides and Allylic Alcohols from Carbonyl Compounds

Desulfinylation of α,β-epoxysulfoxides, easily prepared from carbonyl compounds and 1-chloroalkyl phenyl sulfoxide, with 1 equivalent of butyllithium at low temperature gave epoxides in good yields.The similar α,β-epoxy sulfoxides having an arylmethyl gro

A NOVEL SYNTHESIS OF EPOXIDES AND ALLYLIC ALCOHOLS FROM CARBONYL COMPOUNDS THROUGH α,β-EPOXY SULFOXIDES

Treatment of α,β-epoxy sulfoxides, easily prepared from carbonyl compounds with 1 equivalent of n-butyllithium at -100 deg C gave the desulfinated epoxides in good yields.The similar α,β-epoxy sulfoxides having arylmethyl group at α-position, on treatment