771562-91-5Relevant articles and documents
Catalytic enantioselective Michael addition of 1,3-dicarbonyl compounds to nitroalkenes catalyzed by well-defined chiral Ru amido complexes
Watanabe, Masahito,Ikagawa, Ayako,Wang, Hui,Murata, Kunihiko,Ikariya, Takao
, p. 11148 - 11149 (2004)
Well-defined chiral Ru amido complexes promoted asymmetric Michael addition of 1,3-dicarbonyl compounds including malonates, β-keto esters, and 1,3-diketones to nitroalkenes to give the corresponding adducts with excellent ees and in excellent yields. Cop
Asymmetric synthesis of 3-prenyl-substituted pyrrolidin-2-ones
Sukhanova, Anna A.,Nelyubina, Yulia V.,Zlotin, Sergei G.
, p. 471 - 473 (2016/11/29)
Pharmacology-relevant compounds bearing structural fragments of racetam nootropics, wound-healing acyclic isoprenoids and neurotropic GABA analogues, were enantioselectively (up to 94% ee) synthesized from available and inexpensive precursors.
Multisite organic-inorganic hybrid catalysts for the direct sustainable synthesis of GABAergic drugs
Leyva-Perez, Antonio,Garcia-Garcia, Pilar,Corma, Avelino
supporting information, p. 8687 - 8690 (2014/08/18)
Multisite organic-inorganic hybrid catalysts have been prepared and applied in a new general, practical, and sustainable synthetic procedure toward industrially relevant GABA derivatives. The domino sequence is composed of seven chemical transformations which are performed in two one-pot reactions. The method produces both enantiomeric forms of the product in high enantiopurity as well as the racemate in good yields after a single column purification step. This protocol highlights major process intensification, catalyst recyclability, and low waste generation.