7716-31-6 Usage
Chemical structure
1-phenyl-2-[phenyl(thiophen-2-yl)methylidene]hydrazine
The chemical structure of thiohydrazide consists of a phenyl group (a six-membered aromatic ring with a hydrogen atom) attached to a hydrazine molecule, which in turn has a phenyl group attached to a thiophene ring through a methylene bridge.
Physical appearance
Yellow solid
Thiohydrazide is a yellow-colored solid, which refers to its appearance in its pure form.
Solubility
Insoluble in water, soluble in organic solvents
Thiohydrazide does not dissolve in water but dissolves in organic solvents such as ethanol and ether, which is important for its applications in organic synthesis.
Usage
Building block in organic synthesis and pharmaceutical research
Thiohydrazide is primarily used as a building block in the synthesis of other organic compounds, making it a valuable reagent in the fields of organic synthesis and pharmaceutical research.
Potential mutagen
Hazardous with possible adverse effects
Thiohydrazide is considered a potential mutagen, which means it may cause changes in the genetic material of cells. This property raises concerns about its potential adverse effects on human health and the environment.
Handling and disposal
Handle with care
Due to its hazardous nature, thiohydrazide should be handled and disposed of with care to minimize the risk of exposure and potential harm to humans and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 7716-31-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,7,1 and 6 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 7716-31:
(6*7)+(5*7)+(4*1)+(3*6)+(2*3)+(1*1)=106
106 % 10 = 6
So 7716-31-6 is a valid CAS Registry Number.
7716-31-6Relevant academic research and scientific papers
Transition-Metal-Free Coupling of 1,3-Dipoles and Boronic Acids as a Sustainable Approach to C?C Bond Formation
Livingstone, Keith,Bertrand, Sophie,Kennedy, Alan R.,Jamieson, Craig
, p. 10591 - 10597 (2020/07/25)
The need for alternative, complementary approaches to enable C?C bond formation within organic chemistry is an on-going challenge in the area. Of particular relevance are transformations that proceed in the absence of transition-metal reagents. In the current study, we report a comprehensive investigation of the coupling of nitrile imines and aryl boronic acids as an approach towards sustainable C?C bond formation. In situ generation of the highly reactive 1,3-dipole facilitates a Petasis–Mannich-type coupling via a nucleophilic boronate complex. The introduction of hydrazonyl chlorides as a complementary nitrile imine source to the 2,5-tetrazoles previously reported by our laboratory further broadens the scope of the approach. Additionally, we exemplify for the first time the extension of this protocol into another 1,3-dipole, through the synthesis of aryl ketone oximes from aryl boronic acids and nitrile N-oxides.
