77168-31-1

Basic information

• Product Name: 4-CHLORO-6-METHYL-2-(2-PYRIDINYL)PYRIMIDINE
• Synonyms: 4-CHLORO-6-METHYL-2-(2-PYRIDINYL)PYRIMIDINE;4-CHLORO-2-(2-PYRIDYL)-6-METHYL PYRIMIDINE;4-Chloro-6-methyl-2-pyridin-2-ylpyrimidine
• CAS NO: 77168-31-1
• Molecular Formula: C₁₀H₈ClN₃
• Molecular Weight: 205.64
• Mol File: 77168-31-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 75-76°C
• Boiling Point: 250.3°C at 760 mmHg
• Flash Point: 129.4°C
• Appearance: /
• Density: 1.264g/cm³
• Vapor Pressure: 0.0345mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 4-CHLORO-6-METHYL-2-(2-PYRIDINYL)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-6-METHYL-2-(2-PYRIDINYL)PYRIMIDINE(77168-31-1)
• EPA Substance Registry System: 4-CHLORO-6-METHYL-2-(2-PYRIDINYL)PYRIMIDINE(77168-31-1)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 77168-31-1(Hazardous Substances Data)

Usage

General Description

4-Chloro-6-methyl-2-(2-pyridinyl)pyrimidine is a chemical compound with the molecular formula C10H8ClN3. It is a pyrimidine derivative with a chlorine atom at the 4 position and a methyl group at the 6 position. It also contains a pyridine ring attached at the 2 position. 4-CHLORO-6-METHYL-2-(2-PYRIDINYL)PYRIMIDINE has potential applications in the pharmaceutical industry, particularly in the development of new drugs and pharmaceutical products. It may also have uses in the field of organic synthesis and chemical research. Its specific properties and potential uses may vary depending on the context and the specific goals of the research or application.

InChI:InChI=1/C10H8ClN3/c1-7-6-9(11)14-10(13-7)8-4-2-3-5-12-8/h2-6H,1H3

Upstream product

• 51285-26-8 pyridine-2-carboxamidine hydrochloride 
• 100-70-9 2-Cyanopyridine 
• 55417-80-6 6-methyl-2-(pyridin-2-yl)pyrimidin-4(3H)-one 
• 77168-60-6 pyridine-2-carboxamidinium benzenesulfonate 
• 55417-80-6 6-methyl-2-(pyridin-2'-yl)pyrimidin-4(3H)-one 

Downstream Products

• 438249-13-9 4-(4-Fluoro-3-methoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine 
• 438247-72-4 4-(3-Isopropylanilino)-6-methyl-2-(2-pyridinyl)pyrimidine 
• 438247-88-2 4-(5-Methoxy-2-methylanilino)-6-methyl-2-(2-pyridinyl)pyrimidine 
• 438249-14-0 4-(3-Isopropoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine 
• 438247-87-1 4-(2-Chloro-5-methoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine 
• 438247-69-9 4-(3-Nitroanilino)-6-methyl-2-(2-pyridinyl)pyrimidine 
• 438247-70-2 4-[3-(Methylthio)anilino]-6-methyl-2-(2-pyridinyl)pyrimidine 
• 438248-43-2 4-(2,6-Dimethylanilino)-6-methyl-2-(2-pyridinyl)pyrimidine 
• 438247-71-3 4-(3-Dimethylaminoanilino)-6-methyl-2-(2-pyridinyl)pyrimidine 
• 438249-10-6 6-Methyl-4-(3-phenoxyanilino)-2-(2-pyridinyl)pyrimidine 
• 438249-11-7 4-(3-Chloroanilino)-6-methyl-2-(2-pyridinyl)pyrimidine 
• 438249-12-8 4-(3,4-Dimethoxyanilino)-6-methyl-2-(2-pyridinyl)pyrimidine 
• 438247-42-8 4-(3-Methylanilino)-6-methyl-2-(2-pyridinyl)pyrimidine 

Relevant articles and documents

POTASSIUM CHANNEL MODULATORS

Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with potassium channels.

INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS

Described herein are novel pyrimidine-pyridine compounds, methods of inhibiting methionine aminopeptidase and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, wherein a compound of the invention is administered to a subject.

Unfused Heterobicycles as Amplifiers of Phleomycin.I Some Pyridinyl- and Pyrazolyl-pyrimidines, Bithiazoles and Thiazolylpyridines

Syntheses are reported for some simple derivatives of 2-(pyridin-2'-yl)pyrimidine; 4-(pyrazol-1'-yl)pyrimidine; 4-(pyrazol-4'-yl)pyrimidine; 4,5'-bithiazole; 2-, 3-, and 4-(thiazol-4'-yl)pyridine and 2-, 3-, and 4-(thiazol-2'-yl)pyridine.Biological activities, as amplifiers of phleomycin against in vitro cultures of Escherichia coli, are tabulated and discussed.