77198-50-6

Upstream product

• 7357-70-2 Cyanothioacetamide 
• 104751-33-9 4-(4-methoxyphenyl)-2-phenyl-1,3-butadiene-1,1-dicarbonitrile 
• 123-75-1 pyrrolidine 
• 109-77-3 malononitrile 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 
• 2700-22-3 Benzylidenemalononitrile 
• 22966-19-4 trans-4'-methoxychalcone 

Relevant academic research and scientific papers

A rapid one-pot synthesis of 2,4,6-triaryl-3-aroyl-4-hydroxy-1,1-cyclohexanedicarbonitriles and 2-aminoisophthalonitriles under microwave activation

Ylidenemalononitriles 1 react with a variety of 1,3-diaryl-2-propen-1-ones 2 at ambient temperature and pressure under microwave activation to yield functionalised cyclohexanedicarbonitriles 3 and 2-aminoisophthalonitriles 4 in good yields.

Synthesis of highly substituted 1,6-naphthyridines: A reinvestigation

A reinvestigation of the recently described method of synthesis of highly substituted 1,6-naphthyridines was carried out. It was found out that the reaction of chalcones with malononitrile catalysed by pyrrolidine afforded the mixture of four products both when thermal as well as microwave heating was used. The claimed[1] 1,6-naphthyridines formation were exceptions.

α,β-Unsaturated Nitriles in Organic Synthesis: A Novel Synthesis of Biaryls and Azabiaryls

The reaction of (1-phenylethylidene)malononitrile (2) with cinnamonitrile derivatives 1 a-e afforded the biaryl derivatives 6.The azabiaryls 8 and 10 were synthesized by the reaction of 2 with malononitrile and trichloroacetonitrile.