104751-33-9

Basic information

• Product Name: Propanedinitrile, [3-(4-methoxyphenyl)-1-phenyl-2-propenylidene]-
• CAS NO: 104751-33-9
• Molecular Formula: C19H14N2O
• Molecular Weight: 286.333
• Mol File: 104751-33-9.mol

Chemical Properties

• CAS DataBase Reference: Propanedinitrile, [3-(4-methoxyphenyl)-1-phenyl-2-propenylidene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedinitrile, [3-(4-methoxyphenyl)-1-phenyl-2-propenylidene]-(104751-33-9)
• EPA Substance Registry System: Propanedinitrile, [3-(4-methoxyphenyl)-1-phenyl-2-propenylidene]-(104751-33-9)

Safety Data

• Hazardous Substances Data: 104751-33-9(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 1268249-59-7 C₂₃H₂₁NO₃S 
• 109-77-3 malononitrile 
• 5447-87-0 2-(1-phenylethylidene)propanedinitrile 

Downstream Products

• 1610049-28-9 (E)-diethyl 2-(4-methoxybenzylidene)-4-cyano-5-imino-3-phenylcyclopent-3-ene-1, 1-dicarboxylate 
• 77198-50-6 1-amino-5-(4-methoxyphenyl)-3-phenyl-2,6-benzenedicarbonitrile 

Relevant articles and documents

Synthesis and evaluation of novel 4H-pyrazole and thiophene derivatives derived from chalcone as potential anti-proliferative agents, Pim-1 kinase inhibitors, and PAINS

The chalcone derivatives 3a-d reacted with either malononitrile or ethyl cyanoacetate in ethanol in the presence of catalytic amount of ammonium acetate in an oil bath at 120°C to give the Knowevenagel condensation products 5a-h. The latter compounds reac

Asymmetric synthesis of highly functionalized cyclohexa-1,3-dienes via organocatalyzed one-pot three-component domino reaction of malononitrile with α,β-unsaturated imines

The enantioselective synthesis of highly functionalized cyclohexa-1,3-dienes was achieved via an organocatalytic one-pot three-component domino reaction. In addition, a possible mechanism accounting for the reaction was proposed.

Phosphine-catalyzed annulations between modified allylic derivatives and polar dienes and substituent effect on the annulation mode

In this work, the phosphine-catalyzed annulation reactions between modified allylic derivatives and polar 1,1-dicyano-1,3-dienes have been studied. In the catalysis of PPh3 (20 mol%), a [4+1] annulation reaction is realized between a series of 1,1-dicyano-2,4-diaryl-1,3-dienes and ethoxycarbonyl- activated allylic acetate, producing polysubstituted cyclopentenes in modest to excellent yields. It is also observed that the substituents of both 1,3-dienes and allylic derivatives have a significant influence on the annulation mode: under the catalysis of PPh3 or PBu3 (20 mol%), regioselective [3+2] annulation products are formed from differently substituted substrates. Chemoselective phosphine-catalyzed [4+1] and [3+2] annulations of modified allylic derivatives and polar 1,3-dienes have been realized, and substituent effect on the annulation mode was first observed. Copyright

α,β-Unsaturated Nitriles in Organic Synthesis: A Novel Synthesis of Biaryls and Azabiaryls

The reaction of (1-phenylethylidene)malononitrile (2) with cinnamonitrile derivatives 1 a-e afforded the biaryl derivatives 6.The azabiaryls 8 and 10 were synthesized by the reaction of 2 with malononitrile and trichloroacetonitrile.