77213-46-8Relevant academic research and scientific papers
Synthesis and evaluation of N-Benzyl-acridinone derivatives induced apoptosis in human liver cancer cell-lines
Huang, Xian-Feng,Yulan-Zhua,Zhu, Hai-Liang
, p. 606 - 611 (2012/06/04)
A series of N-benzyl-9(10H)-acridinones were synthesized and tested for their antitumor activities in vitro against HepG2 cells Assay-based antiproliferative activity study using HepG2 cell lines revealed that several compounds had significant effects on cytotoxicity, among which compound 5h was found to be the most active compound with IC50 at about 1.33 μM using the MTT assay. The antitumor effect of compound 5h is believed to be due to the induction of apoptosis, which was further confirmed by Hoechst 33258 fluorescence staining, agarose gel electrophoresis and Annexin VFITC/ PI staining assay using flow cytometry analysis. Above all, compound 5h would be a potential anticancer agent which deserves further research.
NUCLEOPHILIC AROMATIC SUBSTITUTION OF A METHOXY GROUP BY AN ALKYLTHIO GROUP IN THE CASE OF 10-SUBSTITUTED 2-METHOXY-9-THIOACRIDINONES
Dhif, Djeridi,Galy, Jean-Pierre,Barbe, Jacques
, p. 1059 - 1065 (2007/10/02)
The synthesis and nmr study (1H and 13C) of eleven acridine derivatives are reported. 13C Chemical shifts are very sensitive to the oxygen or sulfur nature of the substituents at positions 2 (alkoxy vs thioalkoxy) and 9 (acridinones vs thioacridinones).Th
Alkylation en catalyse par transfert de phase d'une serie d'acridanone-9 substituees: Competition entre O- et N-alkylation
Mahamoud, Abdallah,Galy, Jean-Pierre,Vincent, Emile-Jean,Galy, Anne-Marie,Barbe, Jacques
, p. 503 - 507 (2007/10/02)
Substituted acridanones were alkylated under phase transfer catalysis conditions.In so doing, a mixture of O- and N-alkyl derivatives was prepared.Orientation of the reaction products depends upon the alkylating agent but not on the position of the substi
Alkylation et acetylation d'acridanones. Cas de la methoxy-2 acridanone-9
Chaffia, Brat Ali,Montginoul, Claude,Toreilles, Eliane,Giral, Louis
, p. 345 - 350 (2007/10/02)
The interest of the N-alkylacridanone derivatives lies in their biological properties.We describe the results of various substitution reactions of 2-methoxy-9-acridanone.This substrate, previously metallated by sodium hydride, was reacted with alkyl, allyl, crotyl and benzyl halides and also with alkylamino and acetyl halides in dimethylformamide.A mixture of O-alkyl and N-alkyl isomers, or only one of them, was obtained.The reaction products are interpreted in terms of hardness and softness of reacting centres.
