77216-32-1

Basic information

• Product Name: 2-[2-hydroxy-3-[[2-(5-methoxy-1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]benzonitrile
• CAS NO: 77216-32-1
• Molecular Weight: 393.486
• Mol File: 77216-32-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[2-hydroxy-3-[[2-(5-methoxy-1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-hydroxy-3-[[2-(5-methoxy-1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]benzonitrile(77216-32-1)
• EPA Substance Registry System: 2-[2-hydroxy-3-[[2-(5-methoxy-1H-indol-3-yl)-1,1-dimethylethyl]amino]propoxy]benzonitrile(77216-32-1)

Safety Data

• Hazardous Substances Data: 77216-32-1(Hazardous Substances Data)

Upstream product

• 611-20-1 salicylonitrile 
• 4771-67-9 5-methoxy-3-(2,2-dimethyl-2-nitroethyl)-1H-indole 
• 42864-99-3 (RS)-1-chloro-3-(2-cyanophenoxy)propan-2-ol 
• 16620-52-3 5-methoxygramine 
• 4765-36-0 5-methoxy-α,α,2-trimethyl-1H-indole-3-ethanamine 
• 38465-16-6 1,2-epoxy-3-(2-cyanophenyl)propane 

Relevant articles and documents

Antihypertensive indole derivatives of phenoxypropanolamines with β-adrenergic receptor antagonist and vasodilating activity

A series of 25 aryloxypropanolamines containing the 3-indolyl-tert-butyl[i.e., 1,1-dimethyl-2-(1H-indol-3-yl)ethyl] or substituted 3-indolyl-tert-butyl moiety as the N substituent is reported. These compounds have been tested for antihypertensive activity in spontaneously hypertensive rats (SHR), β-adrenergic receptor antagonist action in conscious normotensive rats, vasodilating activity in ganglion-blocked rats with blood pressure maintained by angiotensin II infusion, and for intrinsic sympathomimetic action (ISA) in reserpinized rats. Some of the compounds exhibit antihypertensive activity in combination with β-adrenergic receptor antagonist and vasodilating action. The structure-activity relationships in these tests are discussed.