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Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate is used as a pharmaceutical intermediate for the synthesis of various medicinal drugs. Its unique chemical structure and functional groups contribute to its potential therapeutic applications, including the development of new drugs for the treatment of various diseases and conditions.
Used in Drug Discovery and Development:
Ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate serves as a key component in drug discovery and development processes. Its chemical properties and reactivity allow for the creation of novel drug candidates with potential therapeutic benefits. Researchers can utilize ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate to explore new chemical entities and optimize their pharmacological profiles for improved efficacy and safety.
Used in Medicinal Chemistry Research:
Ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate is employed as a research tool in medicinal chemistry. Its unique structure and functional groups provide opportunities for studying the interactions between drug molecules and biological targets, such as enzymes, receptors, and other proteins. This knowledge can be applied to design more effective and selective drugs with fewer side effects.

Upstream product

• 53890-44-1 N-methyl 2H-pyrido<2,3-d><1,3>oxazine-2,4-1H-dione 
• 105-53-3 diethyl malonate 
• 1452-94-4 ethyl 2-chloronicotinate 
• 103976-61-0 ethyl 2-(methylamino)pyridine-3-carboxylate 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 21038-63-1 3-azaisatoic anhydride 
• 110457-42-6 methyl 2-(methylamino)nicotinate 

Relevant academic research and scientific papers

Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor

Sphingomyelin synthase 2 (SMS2) has attracted attention as a drug target for the treatment of various cardiovascular and metabolic diseases. The modification of a high throughput screening hit, 2-quinolone 10, enhanced SMS2 inhibition at nanomolar concentrations with good selectivity against SMS1. To improve the pharmaceutical properties such as passive membrane permeability and aqueous solubility, adjustment of lipophilicity was attempted and 1,8-naphthyridin-2-one 37 was identified as a potent and selective SMS2 inhibitor. A significant reduction in hepatic sphingomyelin levels following repeated treatment in mice suggested that compound 37 could be an effective in vivo tool for clarifying the role of SMS2 enzyme and developing the treatment for SMS2-related diseases.

2-Oxo-1,8-naphthyridine-3-carboxylic Acid Derivatives with Potent Gastric Antisecretory Properties

The syntheses of 2-oxo-1,8-naphthyridine-3-carboxylic acid derivatives having potent gastric antisecretory properties in the pyloric-ligated (Shay) rat model are described.Two of the more potent compounds tested that were selected for more detailed dose-r

The Chemistry of 3-Azaisatoic Anhydrides. Synthesis and Reactions of Polyaza Heterocycles

The preparation of a variety of N-substituted 3-azaisotoic anhydrides 3 and 8 is described.These anhydrides reacted with thiopseudoureas to give interesting bicyclic, tricyclic, and tetracyclic heterocycles many of which are new ring systems.One such hete

4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives

4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives are anti-secretory agents for use in the treatment of peptic ulcer disease.

1-Alkyl-4-amino-3-(3-aminotriazolo)-1,8 naphthyridine-2-ones

1-alkyl-4-amino-3-(3-aminotriazolo)-1,8-naphthyridine-2-ones are antihypertensive agents.