77276-17-6

Basic information

• Product Name: ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate
• Synonyms: ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate;ethyl 4-hydroxy-1-Methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-c
• CAS NO: 77276-17-6
• Molecular Formula: C₁₂H₁₂N₂O₄
• Molecular Weight: 248.23468
• Mol File: 77276-17-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate(77276-17-6)
• EPA Substance Registry System: ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate(77276-17-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 77276-17-6(Hazardous Substances Data)

Usage

General Description

Ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate is a chemical compound that belongs to the class of naphthyridine carboxylates. It is a derivative of 1,8-naphthyridine with a carboxylic ester functional group. ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate has potential pharmaceutical properties and may be used in the development of medicinal drugs. It is important to note that this compound is not approved for any specific medical or commercial use and should be handled with caution. Additionally, further research and testing are needed to fully understand its potential applications and effects.

Upstream product

• 1452-94-4 ethyl 2-chloronicotinate 
• 103976-61-0 ethyl 2-(methylamino)pyridine-3-carboxylate 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 21038-63-1 3-azaisatoic anhydride 
• 110457-42-6 methyl 2-(methylamino)nicotinate 
• 53890-44-1 N-methyl 2H-pyrido<2,3-d><1,3>oxazine-2,4-1H-dione 
• 105-53-3 diethyl malonate 

Relevant articles and documents

Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor

Sphingomyelin synthase 2 (SMS2) has attracted attention as a drug target for the treatment of various cardiovascular and metabolic diseases. The modification of a high throughput screening hit, 2-quinolone 10, enhanced SMS2 inhibition at nanomolar concentrations with good selectivity against SMS1. To improve the pharmaceutical properties such as passive membrane permeability and aqueous solubility, adjustment of lipophilicity was attempted and 1,8-naphthyridin-2-one 37 was identified as a potent and selective SMS2 inhibitor. A significant reduction in hepatic sphingomyelin levels following repeated treatment in mice suggested that compound 37 could be an effective in vivo tool for clarifying the role of SMS2 enzyme and developing the treatment for SMS2-related diseases.

The Chemistry of 3-Azaisatoic Anhydrides. Synthesis and Reactions of Polyaza Heterocycles

The preparation of a variety of N-substituted 3-azaisotoic anhydrides 3 and 8 is described.These anhydrides reacted with thiopseudoureas to give interesting bicyclic, tricyclic, and tetracyclic heterocycles many of which are new ring systems.One such hete

1-Alkyl-4-amino-3-(3-aminotriazolo)-1,8 naphthyridine-2-ones

1-alkyl-4-amino-3-(3-aminotriazolo)-1,8-naphthyridine-2-ones are antihypertensive agents.