773092-62-9Relevant academic research and scientific papers
The discovery and preparation of disubstituted novel amino-aryl-piperidine- based renin inhibitors
Cody, Wayne L.,Holsworth, Daniel D.,Powell, Noel A.,Jalaie, Mehran,Zhang, Erli,Wang, Wei,Samas, Brian,Bryant, John,Ostroski, Robert,Ryan, Michael J.,Edmunds, Jeremy J.
, p. 59 - 68 (2007/10/03)
Recently, trans-disubstituted oxo-aryl-piperidines have been identified as small molecule nonpeptide renin inhibitors for the modulation of hypertension. Herein, we report on the discovery and preparation of a new class of novel cis-disubstituted amino-aryl-piperidines as a mixture of enantiomers that are potent in vitro renin inhibitors and also, possess in vivo antihypertensive activity in a double transgenic mouse model.
Piperidine derivative rennin inhibitors
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Page/Page column 20-21, (2010/02/08)
Disclosed are piperidine derivatives, their manufacture and use as inhibitors of renin.
PIPERAZINE DERIVATIVE RENIN INHIBITORS
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Page 66-67, (2010/02/09)
Disclosed are piperazine derivatives, their manufacture and use as inhibitors of renin. Formula (I):
