773092-64-1Relevant academic research and scientific papers
The discovery and preparation of disubstituted novel amino-aryl-piperidine- based renin inhibitors
Cody, Wayne L.,Holsworth, Daniel D.,Powell, Noel A.,Jalaie, Mehran,Zhang, Erli,Wang, Wei,Samas, Brian,Bryant, John,Ostroski, Robert,Ryan, Michael J.,Edmunds, Jeremy J.
, p. 59 - 68 (2005)
Recently, trans-disubstituted oxo-aryl-piperidines have been identified as small molecule nonpeptide renin inhibitors for the modulation of hypertension. Herein, we report on the discovery and preparation of a new class of novel cis-disubstituted amino-aryl-piperidines as a mixture of enantiomers that are potent in vitro renin inhibitors and also, possess in vivo antihypertensive activity in a double transgenic mouse model.
Piperidine derivative rennin inhibitors
-
Page/Page column 21-22, (2010/02/08)
Disclosed are piperidine derivatives, their manufacture and use as inhibitors of renin.
Piperidine derivatives having renin inhibiting activity
-
, (2008/06/13)
Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I wherein R1, R2, R3, R4, Q, X, Z, m and n are as described herein.
