773108-64-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-2,5-Difluorobenzoic Acid is utilized as a building block for the synthesis of pharmaceutical drugs. Its unique structure allows for the development of new drug candidates with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Amino-2,5-Difluorobenzoic Acid serves as a key component in the creation of agrochemicals, contributing to the advancement of crop protection and management solutions.
Used in Research and Development:
4-Amino-2,5-Difluorobenzoic Acid is employed as a reagent in organic chemistry reactions, facilitating research and development efforts in the scientific community.
Used in Materials Science:
4-Amino-2,5-Difluorobenzoic Acid has been studied for its potential applications in materials science, indicating its capacity to contribute to the development of innovative materials with specific properties.
Used in Drug Development:
4-Amino-2,5-Difluorobenzoic Acid is recognized for its role in the development of new drug candidates, highlighting its significance in the pharmaceutical and medicinal chemistry fields.

InChI:InChI=1/C7H5F2NO2/c8-4-2-6(10)5(9)1-3(4)7(11)12/h1-2H,10H2,(H,11,12)

Upstream product

• 112279-60-4 4-bromo-2,5-difluoroaniline 
• 98349-22-5 2,4,5-trifluorobenzonitrile 
• 112279-61-5 4-amino-2,5-difluoro-benzonitrile 
• 116465-48-6 2,5‐difluoro‐4‐nitrobenzoic acid 

Downstream Products

• 952285-52-8 methyl 4-amino-2,5-difluorobenzoate 
• 1346764-05-3 ethyl 4-amino-2,5-difluorobenzoate 
• 1346764-06-4 4-amino-2,5-difluorophenylmethanol 
• 1124213-74-6 N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-2,5-difluorobenzoyl)piperazin-1-yl)methyl)-benzamide 
• 1124213-76-8 3-((4-(4-amino-2,5-difluorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide 
• 1001347-60-9 4-amino-2,5-difluoro-N-[[1-(pyrrolidin-1-ylmethyl)cyclopropyl]methyl]benzamide 
• 1001347-30-3 4-amino-2,5-difluoro-N-[(3R)-1-methylpyrrolidin-3-yl]benzamide 
• 1001347-65-4 4-amino-2,5-difluoro-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]non-7-yI]benzamide 

Relevant academic research and scientific papers

Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment

Human dihydroorotate dehydrogenase (hDHODH), as the fourth and rate-limiting enzyme of the de novo pyrimidine synthesis pathway, is regarded as an attractive target for malignancy therapy. In the present study, a novel series of teriflunomide derivatives were designed, synthesized, and evaluated as hDHODH inhibitors. 13t was the optimal compound with promising enzymatic activity (IC50 = 16.0 nM), potent antiproliferative activity against human lymphoma Raji cells (IC50 = 7.7 nM), and excellent aqueous solubility (20.1 mg/mL). Mechanistically, 13t directly inhibited hDHODH and induced cell cycle S-phase arrest in Raji cells. The acute toxicity assay indicated a favorable safety profile of 13t. Notably, 13t displayed significant tumor growth inhibition activity with a tumor growth inhibition (TGI) rate of 81.4% at 30 mg/kg in a Raji xenograft model. Together, 13t is a promising inhibitor of hDHODH and a preclinical candidate for antitumor therapy, especially for lymphoma.

Mechanistic Evaluation of Bioorthogonal Decaging with trans-Cyclooctene: The Effect of Fluorine Substituents on Aryl Azide Reactivity and Decaging from the 1,2,3-Triazoline

Bioorthogonal prodrug activation/decaging strategies need to be selective, rapid and release the drug from the masking group upon activation. The rates of the 1,3-dipolar cycloaddition between a trans-cyclooctene (TCO) and a series of fluorine-substituted

NEW CYCLOHEXYLAMINE DERIVATIVES HAVING β2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES

The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

N-BENZYL,N'-ARYLCARBONYLPIPERAZINE DERIVATIVES

The present invention relates to N-benzyl,N′-arylcarbonylpiperazine derivatives having the general formula I to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N′-arylcarbonylpiperazine derivatives for the manufacture o

N-BENZYL, N'-ARYLCARBONYLPIPERAZINE DERIVATIVES AS LXR MODULATORS

The present invention relates to N-benzyl,N'-arylcarbonylpiperazine derivatives having the general Formula (I) to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N'-arylcarbonylpiperazine derivatives for the manufacture

Thiazolyl-Dihydro-Indazole

The present invention encompasses compounds of general formula (1) wherein R1 to R5 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use th