4-Amino-2,5-difluorobenzoic acid

Base Information

Chemical Name:4-Amino-2,5-difluorobenzoic acid
CAS No.:773108-64-8
Molecular Formula:C7H5F2NO2
Molecular Weight:173.119
Hs Code.:2922498590
European Community (EC) Number:676-402-0
DSSTox Substance ID:DTXSID70603007
Wikidata:Q72435853
Mol file:773108-64-8.mol

Synonyms:4-Amino-2,5-difluorobenzoic acid;773108-64-8;4-Amino-2,5-difluorobenzoicacid;MFCD06208208;4-amino-2,5-difluoro-benzoic acid;SCHEMBL99199;DTXSID70603007;YOXMTBAQSNCVJQ-UHFFFAOYSA-N;2,5-difluoro-4-aminobenzoic acid;AMY16090;CL8910;AKOS006293764;AC-28704;SY035100;TS-02365;DB-075283;A9784;CS-0105580;EN300-224466;Z1198167170

Suppliers and Price of 4-Amino-2,5-difluorobenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Amino-2,5-difluorobenzoicAcid
100mg
$ 75.00

Matrix Scientific
4-Amino-2,5-difluorobenzoic acid 97%
1g
$ 617.00

Chemenu
4-Amino-2,5-difluorobenzoicacid 95%
25g
$ 515.00

Chemenu
4-Amino-2,5-difluorobenzoicacid 95%
10g
$ 275.00

Apolloscientific
4-Amino-2,5-difluorobenzoicacid 95%
5g
$ 140.00

Apolloscientific
4-Amino-2,5-difluorobenzoicacid 95%
1g
$ 40.00

Apolloscientific
4-Amino-2,5-difluorobenzoicacid 95%
25g
$ 550.00

American Custom Chemicals Corporation
4-AMINO-2,5-DIFLUOROBENZOIC ACID 95.00%
100G
$ 9009.00

American Custom Chemicals Corporation
4-AMINO-2,5-DIFLUOROBENZOIC ACID 95.00%
20G
$ 4015.00

Ambeed
4-Amino-2,5-difluorobenzoicacid 97%
25g
$ 647.00

Total 44 raw suppliers

Chemical Property of 4-Amino-2,5-difluorobenzoic acid

Chemical Property:

Vapor Pressure:0.000172mmHg at 25°C
Refractive Index:1.578
Boiling Point:316.5 °C at 760 mmHg
PKA:3.59±0.10(Predicted)
Flash Point:145.2 °C
PSA：63.32000
Density:1.536 g/cm³
LogP:1.82640
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:173.02883473
Heavy Atom Count:12
Complexity:188

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-2,5-difluorobenzoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=CC(=C1F)N)F)C(=O)O

Technology Process of 4-Amino-2,5-difluorobenzoic acid

There total 4 articles about 4-Amino-2,5-difluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 112279-61-5
4-amino-2,5-difluoro-benzonitrile

: 773108-64-8
4-amino-2,5-difluoro-benzoic acid

Guidance literature:: With potassium hydroxide; In water; at 100 ℃;
DOI:10.1021/acs.bioconjchem.7b00665

Reference yield:

: 116465-48-6
2,5‐difluoro‐4‐nitrobenzoic acid

: 773108-64-8
4-amino-2,5-difluoro-benzoic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; under 3000.3 Torr;

Reference yield:

: 98349-22-5
2,4,5-trifluorobenzonitrile

: 773108-64-8
4-amino-2,5-difluoro-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / 6 h / 130 °C / High pressure; Autoclave

2: potassium hydroxide / water / 20 h / 100 °C

With ammonium hydroxide; potassium hydroxide; In water;
DOI:10.1021/acs.jmedchem.1c01711