952285-52-8

Usage

Uses

Used in Pharmaceutical Development:
Benzoic acid, 4-Amino-2,5-difluoro-, Methyl ester is used as a building block in pharmaceutical development for the synthesis of various organic molecules, such as pharmaceuticals and agrochemicals. Its unique structure and potential biological activity make it a valuable precursor in the development of new drugs and bioactive compounds.
Used in Research:
Benzoic acid, 4-aMino-2,5-difluoro-, Methyl ester is also used in research settings to study its properties and potential applications. Researchers can use Benzoic acid, 4-Amino-2,5-difluoro-, Methyl ester to explore its reactivity, stability, and interactions with other molecules, which can contribute to the advancement of scientific knowledge and the discovery of new applications.
It is important to handle Benzoic acid, 4-Amino-2,5-difluoro-, Methyl ester with care, as it can be toxic if ingested or inhaled and can cause skin and eye irritation. Proper safety measures should be taken during its use to minimize potential risks.

Upstream product

• 112279-61-5 4-amino-2,5-difluoro-benzonitrile 
• 112279-60-4 4-bromo-2,5-difluoroaniline 
• 1193162-21-8 4-bromo-2,5-difluoro-benzoic acid methyl ester 
• 28314-82-1 4-bromo-2,5-difluorobenzoic acid 
• 327-51-5 1,4-dibromo-2,5-difluorobenzene 
• 67-56-1 methanol 
• 773108-64-8 4-amino-2,5-difluoro-benzoic acid 

Downstream Products

• 1613730-91-8 methyl 4-amino-2,5-difluoro-3-iodobenzoate 
• 1613730-92-9 methyl 4-amino-2,5-difluoro-3-((trimethylsilyl)ethynyl)benzoate 

Relevant academic research and scientific papers

Mechanistic Evaluation of Bioorthogonal Decaging with trans-Cyclooctene: The Effect of Fluorine Substituents on Aryl Azide Reactivity and Decaging from the 1,2,3-Triazoline

Bioorthogonal prodrug activation/decaging strategies need to be selective, rapid and release the drug from the masking group upon activation. The rates of the 1,3-dipolar cycloaddition between a trans-cyclooctene (TCO) and a series of fluorine-substituted

SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

Provided is a sulfonamide derivative represented by the following general formula (1) and having an α4 integrin inhibitory effect with high selectivity with a low effect on α4β1 and a high effect on α4β7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R41, and a to h are as described in the description).

SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF

Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent α4 integrin-inhibitory action.

Thiazolyl-Dihydro-Indazole

The present invention encompasses compounds of general formula (1) wherein R1 to R5 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use th