773143-72-9

Upstream product

• 1001909-49-4 C₁₆H₂₁NO₅ 
• 7677-24-9 trimethylsilyl cyanide 
• 77-76-9 2,2-dimethoxy-propane 
• 773143-70-7 Acetic acid (3S,4S)-4-acetoxy-2-cyano-1-(4-methoxy-benzyl)-5-oxo-pyrrolidin-3-yl ester 

Downstream Products

• 236751-52-3 (2R,3S,4S)-3,4-dihydroxyglutamic acid 

Relevant academic research and scientific papers

Total synthesis of (-)-2-epi-lentiginosine by use of chiral 5-hydroxy-1,5-dihydropyrrol-2-one as a building block

We have developed a practical synthesis of the chiral lactam as a new chiral building block for alkaloid synthesis. Lipase-catalyzed kinetic resolution of hydroxylactam 8, followed by isolation-racemization of the chiral acetoxylactam 9 provided the optic

Asymmetric synthesis of 3,4-dihydroxyglutamic acids via enantioselective reduction of cyclic meso-imide

Stereoselective synthesis of (3S,4S)- and (3R,4R)-series of 3,4-dihydroxyglutamic acids was investigated. The key reaction in this synthesis is asymmetric reduction of meso-imide derived from meso-tartaric acid. Lewis acid-promoted cyanation of the obtained optically active lactam via the acyliminium intermediate followed by standard deprotection procedure afforded the desired 3,4-dihydroxyglutamic acids. Graphical abstract