773147-13-0Relevant academic research and scientific papers
Synthetic routes to N-Pmc-N′,N″-disubstituted guanidines via EDCI-mediated guanylation of amines with N-Pmc-N′-substituted thioureas
Flemer Jr., Stevenson,Madalengoitia, Jose S.
, p. 1848 - 1860 (2008/02/10)
An overview of the facile and high-yielding EDCI-mediated reaction of amines with N-Pmc-N′-alkyl thioureas to afford guanidines is presented, in which the general scope and limitations of the reaction are probed. It was found that the N-sulfonyl-N′-substi
A 1,3-Diaza-Claisen rearrangement that affords guanidines
Bowser, Amy M.,Madalengoitia, Jose S.
, p. 3409 - 3412 (2007/10/03)
(Chemical Equation Presented) N-Alkyl-N′-tosylthioureas activated by EDCI react with azanorbonenes at room temperature through a 1,3-diaza-Claisen rearrangement, affording highly substituted, bicyclic guanidines in moderate to good yields.
