77326-62-6

Basic information

• Product Name: 2-AMINO-6-BROMOBENZONITRILE
• Synonyms: 2-AMINO-6-BROMOBENZONITRILE;2-Amino-6-bromobenzonitrile 97%;3-Bromo-2-cyanoaniline;Bromo-6-amino-benzonitrile
• CAS NO: 77326-62-6
• Molecular Formula: C₇H₅BrN₂
• Molecular Weight: 197.04
• Mol File: 77326-62-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 152-154℃
• Boiling Point: 343.338 °C at 760 mmHg
• Flash Point: 161.445 °C
• Appearance: Off-white/Powder
• Density: 1.68
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.74±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-6-BROMOBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6-BROMOBENZONITRILE(77326-62-6)
• EPA Substance Registry System: 2-AMINO-6-BROMOBENZONITRILE(77326-62-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 77326-62-6(Hazardous Substances Data)

Usage

General Description

2-Amino-6-bromobenzonitrile is a chemical compound with the molecular formula C7H5BrN2. It is a derivative of benzonitrile, a colorless liquid with a bitter almond odor that is used in the production of pharmaceuticals, dyes, and pesticides. 2-Amino-6-bromobenzonitrile is a solid at room temperature and is considered to be a hazardous substance. It is primarily used in the synthesis of various organic compounds and is also known to have potential biological activity, making it of interest to researchers in the pharmaceutical industry. Handling and storage of 2-Amino-6-bromobenzonitrile should be done with caution to avoid potential health and environmental hazards.

InChI:InChI=1/C7H5BrN2/c8-6-2-1-3-7(10)5(6)4-9/h1-3H,10H2

Upstream product

• 79544-27-7 2-bromo-6-fluorobenzonitrile 
• 77326-36-4 2-amino-6-fluorobenzonitrile 
• 1897-52-5 2,6 difluorobenzonitrile 
• 2042-37-7 o-cyanobromobenzene 
• 606-21-3 1-chloro-2,6-dinitrobenzene 
• 63365-23-1 2-amino-6-nitrobenzonitrile 
• 35213-00-4 2,6-dinitrobenzonitrile 
• 20780-72-7 4-bromoisatin 
• 77326-61-5 4-Bromo-1H-indole-2,3-dione 3-oxime 
• 79603-02-4 2-bromo-6-nitrobenzonitrile 

Downstream Products

• 6575-12-8 2,6-dibromobenzonitrile 
• 608-30-0 2,6-dibromoaniline 
• 1093205-64-1 2-sulfamoylamino-6-(tetrahydrofuran-2-yl)benzonitrile 
• 1093205-63-0 2-amino-6-(4,5-dihydrofuran-2-yl)benzonitrile 
• 1093205-62-9 2-sulfamoylamino-6-(4,5-dihydrofuran-2-yl)benzonitrile 
• 1337543-22-2 2-amino-6-(3,3-dimethylbutyl)benzonitrile 
• 1337547-31-5 2-amino-6-(cyclohexylethynyl)benzonitrile 
• 1337543-23-3 2-amino-6-(3,3-dimethylbut-1-ynyl)benzonitrile 
• 1272356-31-6 N-(tert-butyl)-5-(5-phenyl-4-((pyridin-2ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide 
• 1272356-75-8 5-(4-amino-5-phenylquinazolin-2-yl)-N-tert-butylpyridine-3-sulfonamide 
• 1272353-82-8 5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide 
• 77326-30-8 N-(3-Bromo-2-cyano-phenyl)-oxalamic acid ethyl ester 
• 119584-75-7 5-bromo-2,4-diaminoquinazoline 
• 1337547-35-9 ethyl 4-amino-5-(3-methoxyphenyl)-2-methylquinoline-3-carboxylate 

Relevant articles and documents

Preparation method of 2,6-dibromoaniline

The invention discloses a preparation method of 2,6-dibromoaniline. According to the method, 2,6-difluorobenzonitrile is used as an initial raw material, and the 2,6-dibromoaniline is synthesized through six steps of reactions including ammonolysis, diazotization bromination, re-ammonolysis, re-diazotization bromination, amidation and Hofmann degradation. The 2,6-dibromoaniline obtained in the process is a brown solid, and the purity of the 2,6-dibromoaniline is 98% or above.

TETRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME

Described herein are tetrazole compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tetrazole compounds are provided. The compounds are contemplated to have activity against meth

Antifolate and Antibacterial Activities of 5-Substituted 2,4-Diaminoquinazolines

A series of 5-substituted 2,4-diaminoquinazolines (3) has been synthesized and evaluated as inhibitors of the enzyme dihydrofolate reductase (DHFR) from both bacterial and mammalian sources.The best compounds (e.g. 53) show good activity against Escherichia coli DHFR, but there is no significant selectivity for the bacterial over the mammalian enzyme.The structure-activity relationships for enzyme inhibition appear to be complex and not amenable to simple analysis; a hypotesis to explain the observed qualitative structure-activity relationships is proposed.The inhibitory activities of the compounds against the growth of intact bacterial cells in vitro closely parallel those for the inhibition of the isolated bacterial enzymes, suggesting that their antifolate action is responsible for their antibacterial effects.Five of the compounds were tested for their ability to cure a systemic E. coli infection in the mouse, but they showed no therapeutic effects at their maximum tolerated doses.