77328-29-1

Upstream product

• 67-56-1 methanol 
• 32945-04-3 N-carboxymethyl-L-phenylalanine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 96-32-2 bromoacetic acid methyl ester 
• 96-34-4 methyl chloroacetate 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 63-91-2 L-phenylalanine 
• 77328-32-6 benzyl N-benzyloxycarbonylmethyl-L-phenylalaninate 

Downstream Products

• 860541-93-1 N-methoxycarbonylmethyl-N-phenylcarbamoyl-phenylalanine methyl ester 
• 849586-60-3 N-(2-amino-ethyl)-2-{[(2-amino-ethylcarbamoyl)-methyl]-amino}-3-phenyl-propionamide 
• 77328-41-7 methyl N-carboxymethyl-L-phenylalaninate 
• 32945-04-3 N-carboxymethyl-L-phenylalanine 

Relevant academic research and scientific papers

A convenient synthesis of chiral dioxocyclens and application as chiral solvating agents

This paper reports a very short and efficient synthesis of chiral dioxocyclens starting from natural amino acids. NMR experiments were undertaken to assess the chiral recognition properties of these chiral macrocycles. The NMR spectra of mandelic acid or its derivatives in the presence and absence of the chiral dioxocyclens showed that these macrocycles have different enantiomeric discriminating ability. It was revealed that this type of dioxocyclen may be promising hosts for chiral discrimination.

The synthesis of new chiral dioxocyclens

This article reports a short and efficient synthesis of chiral dioxocyclens starting from natural amino acids. Four new chiral dioxocyclens that contain different substituents at the chiral center were obtained. These dioxocyclens could not only be used f

Synthesis and chiral recognition of novel chiral fluorescence receptors bearing 9-anthryl moieties

Two chiral fluorescence receptors 1 and 2 have been synthesized, and their structures characterized by IR, 1H NMR, MS spectra and elemental analysis. The chiral recognition of the receptors was studied by 1H NMR and fluorescence spectra. The results demonstrate that the receptors and tetrabutylammonium mandelate formed a 1:1 complex. Two receptors exhibit good chiral recognition abilities towards the enantiomers of tetrabutylammonium mandelate.

LiOH-mediated N-monoalkylation of α-amino acid esters and a dipeptide ester using activated alkyl bromides

Selective N-monoalkylation of α-amino esters with activated alkyl bromides was studied using various alkali or alkali earth metal bases. In the production of N-monoalkylated amino ester derivatives and suppression of N,N-dialkylation, lithium hydroxide wa