77331-28-3

Usage

Class

1,2,4-triazoles

Uses

a. Synthesis of pharmaceuticals and agrochemicals
b. Catalyst or reagent in various organic reactions
c. Potential applications in material science and medicinal chemistry

Physical state

Yellow crystalline solid

Molecular weight

325.84 g/mol

Biological and pharmacological properties

May have properties of interest for further research and development

Upstream product

• 64-18-6 formic acid 
• 54211-56-2 3-methyl-1,4-diphenyl isothiosemicarbazide 
• 54211-56-2 S-methyl-1,4-diphenylisothiosemicarbazide 

Downstream Products

• 77331-33-0 5-Heptyl-3-methylsulfanyl-1,4-diphenyl-4H-[1,2,4]triazol-1-ium; iodide 
• 77331-35-2 5-(3,7-Dimethyl-octyl)-3-methylsulfanyl-1,4-diphenyl-4H-[1,2,4]triazol-1-ium; iodide 
• 77331-36-3 3-Methylsulfanyl-5-((Z)-octadec-9-enyl)-1,4-diphenyl-4H-[1,2,4]triazol-1-ium; iodide 
• 77331-34-1 5-(7-Methoxy-3,7-dimethyl-octyl)-3-methylsulfanyl-1,4-diphenyl-4H-[1,2,4]triazol-1-ium; iodide 
• 77331-30-7 5-(Hydroxy-phenyl-methyl)-3-methylsulfanyl-1,4-diphenyl-4H-[1,2,4]triazol-1-ium; chloride 
• 77331-29-4 5-(1-Hydroxy-ethyl)-3-methylsulfanyl-1,4-diphenyl-4H-[1,2,4]triazol-1-ium; chloride 
• 113899-27-7 5-(methoxycarbonylmethylene)-3-methylthio-1,4-diphenyl-4,5-dihydro-1,2,4-triazole 
• 77331-32-9 5-Isobutyl-3-methylsulfanyl-1,4-diphenyl-4H-[1,2,4]triazol-1-ium; iodide 
• 113899-32-4 5-(acetylmethylene)-3-methylthio-1,4-diphenyl-4,5-dihydro-1,2,4-triazole 
• 113899-31-3 5-(benzoylmethylene)-3-methylthio-1,4-diphenyl-4,5-dihydro-1,2,4-triazole 
• 113899-35-7 2-[5-Methylsulfanyl-2,4-diphenyl-2,4-dihydro-[1,2,4]triazol-(3E)-ylidene]-3-oxo-butyric acid methyl ester 
• 113899-28-8 5-(benzoyl-methoxycarbonylmethylene)-3-methylthio-1,4-diphenyl-4,5-dihydro-1,2,4-triazole 
• 38054-60-3 5-methyl-3-methylthio-1,4-diphenyl-1,2,4-triazolium iodide 
• 77331-31-8 5-Chloromethyl-3-methylsulfanyl-1,4-diphenyl-4H-[1,2,4]triazol-1-ium; chloride 

Relevant academic research and scientific papers

STABLE CARBON-YLIDES

5-Acylmethylene-1,2,4-triazolium salts were synthesized and converted to stable anhydrobases by aqueous alkali.The close analogy of their spectra with those of phosphorus-ylides and their reactions suggest that the anhydrobases may be regarded as carbon-ylides. α,β-Unsaturated aldehydes were synthesized in moderate yield by selective reduction of the salts folloved by acid hydrolysis.

THE CHAIN LENGTHENING OF ALIPHATIC ALDEHYDES WITH THE AID OF "NUCLEOPHILIC CARBENE"

The addition of "nucleophilic carbene" on 1,2,4-triazole bases (2) and aldehydes is decisively influenced by the anion present. 5-(α-Hydroxyalkyl)-1,2,4-triazolium chlorides, formed in the addition reaction of 3-methylthio-1,4-diphenyl-1,2,4-triazolium chloride (1c) with aldehydes, can be easily reduced to 5-alkyl-1,2,4-triazolium iodides (5).Reduction of these with NaBH4 affords aldehydes by acidic hydrolysis or carboxylic acids by alkaline hydrolysis, the carbon chain of which has been lengthened by one CH2 group, as compared to the starting aldehyde.