77336-92-6Relevant academic research and scientific papers
Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents
Plutín, Ana M.,Alvarez, Anislay,Mocelo, Raúl,Ramos, Raúl,Castellano, Eduardo E.,da Silva, Monize M.,Villarreal, Wilmer,Pavan, Fernando R.,Meira, Cássio Santana,Filho, José Sim?o Rodrigues,Moreira, Diogo Rodrigo M.,Soares, Milena Botelho P.,Batista, Alzir A.
, p. 70 - 77 (2017/05/24)
The new complexes of Pd(II) with N,N-disubstituted-N′-acylthioureas:[(1) [Pd(dppf)(N,N-dimethyl-N′-benzoylthioureato-k2O,S)]PF6, (2) [Pd(dppf)(N,N-diethyl-N′-benzoylthioureato-k2O,S)]PF6, (3) [Pd(dppf)(N,N-dibut
Anti-Mycobacterium tuberculosis activity of platinum(II)/N,N-disubstituted-N′-acyl thiourea complexes
Plutín, Ana M.,Alvarez, Anislay,Mocelo, Raúl,Ramos, Raúl,Castellano, Eduardo E.,Da Silva, Monize M.,Colina-Vegas, Legna,Pavan, Fernando R.,Batista, Alzir A.
, p. 74 - 80 (2015/12/18)
Synthesis, characterization and anti-Mycobacterium tuberculosis assays of new platinum(II)/dppf/N,N-disubstituted-N′-acyl thiourea complexes with general formulae [Pt(dppf)(L)]PF6, [dppf = 1,1′-bis(diphenylphosphino)ferrocene; L = N,N-disubstit
On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted- N′-acyl thioureas
Plutín, Ana M.,Mocelo, Raúl,Alvarez, Anislay,Ramos, Raúl,Castellano, Eduardo E.,Cominetti, Marcia R.,Graminha, Angelica E.,Ferreira, Antonio G.,Batista, Alzir A.
, p. 76 - 82 (2014/03/21)
The rational design of anticancer drugs is one of the most promising strategies for increasing their cytotoxicity and for minimizing their toxicity. Manipulation of the structure of ligands or of complexes represents a strategy for which is possible to mo
Synthesis and structural characterization of cobalt(II) and copper(II) complexes with N,N-disubstituted-N′-acylthioureas
O'Reilly, Beatriz,Plutin, Ana M.,Perez, Hiram,Calderon, Osmar,Ramos, Raul,Martinez, Roberto,Toscano, Ruben A.,Duque, Julio,Rodriguez-Solla, Humberto,Martinez-Alvarez, Roberto,Suarez, Margarita,Martin, Nazario
experimental part, p. 133 - 140 (2012/05/20)
A new complexes of Co(II) and Cu(II) with N,N-disubstituted-N′- acylthioureas have been prepared and characterized by elemental analysis, and spectroscopic techniques. The structure of N,N-diethyl-N′-furoylthiourea and Co(II) complexes with N,N-diethyl-N′
Synthesis of mono- and N,N-disubstituted thioureas and N-acylthioureas
Katritzky, Alan R.,Kirichenko, Nataliya,Rogovoy, Boris V.,Kister, Jeremy,Tao, Hui
, p. 1799 - 1805 (2007/10/03)
1-Benzotriazole-1-carbothioamide (2), prepared from 1-cyanobenzotriazole (1) and hydrogen sulfide, reacts with amines to give thioureas 3a-e. Reactions of (benzotriazol-1-yl)carboximidamides 4a-d,f-j and acyl- 5a-f,i-k or arylaminocarbonyl- 5g,h (benzotri
A calorimetric study of N,N-diethyl-N′-furoylthiourea and N,N-diisobutyl-N′-furoylthiourea
Ribeiro Da Silva, Manuel A. V.,Ribeiro Da Silva, Maria D. M. C.,Da Silva, Luis C. M.,Dietze, Frank
, p. 155 - 161 (2007/10/03)
The standard (po = 0.1 MPa) molar enthalpies of combustion in oxygen, at T = 298.15 K, were measured by rotative bomb calorimetry for crystalline N,N-diethyl-N′-furoylthiourea, (2-C4H3O)CONHCSN(C2H5) 2, HFET, and N,N-diisobutyl-N′-furoylthiourea, (2-C4H3O)CONHCSN(iso-C4H9) 2, HFIB. The standard molar enthalpies of sublimation of both HFET and HFIB were measured by high-temperature Calvet microcalorimetry. These values were used to derive the standard molar enthalpies of formation of the compounds, in their crystalline and gaseous phases.
Aroylthioureas: New organic ionophores for heavy-metal ion selective electrodes
Otazo-Sanchez, Elena,Perez-Marin, Leonel,Estevez-Hernandez, Osvaldo,Rojas-Lima, Susana,Alonso-Chamarro, Julian
, p. 2211 - 2218 (2007/10/03)
Thiourea derivatives (46 aroylthioureas) having different substituents close to the sulfur atom were synthesized and their ionophore potential in ion selective electrodes (ISEs) was examined. Structural considerations were taken into account based on the corresponding heavy-metal ISE parameters. As ionophores, some 1-furoyl-3-substitnted thioureas (series 2) gave the best results in Pb(II), Hg(II) and Cd(II) ISEs. The strong intramolecular hydrogen bond in series 2 allows ligand interaction only through the C=S group. Substituents on the furan and phenyl rings give rise to low solubility in the membrane plasticizer. 3-Alkyl substituted furoylthioureas improve solubility but enhance oxidative processes with chain length. New X-ray diffraction (XRD) structures and theoretical DFT calculations were considered in the analysis of the substituent influence on the selectivity of ISEs. These new ionophores have advantages because of their stability, simple synthesis and easy modification of the sulfur binding ability resulting from substitution.
INVESTIGATIONS IN THE SERIES OF ACYLTHIOUREAS. ACIDITY IN DIMETHYLFORMAMIDE
Masias, A.,Otazo, E.,Beletskaya, I. P.
, p. 591 - 594 (2007/10/02)
The pKa values of three series of substituted 1-furoyl- and 1-benzoyl-3-arylthioureas were determined in dimethylformamide.It was shown that the investigated acylthioureas are more acidic than pyridine-substituted thioureas and substituted thio
