77342-37-1

Usage

Uses

Used in Pharmaceutical Industry:
5,5,5-Trifluoropent-1-en-4-ol is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs with improved properties.
Used in Agrochemical Industry:
5,5,5-Trifluoropent-1-en-4-ol is used as a precursor in the production of agrochemicals, aiding in the creation of more effective and environmentally friendly pesticides and fertilizers.
Used in Organic Synthesis:
5,5,5-Trifluoropent-1-en-4-ol is used as a versatile intermediate in organic synthesis, enabling the synthesis of complex organic molecules for various applications.
Used in Chemical Reactions:
5,5,5-Trifluoropent-1-en-4-ol is used as a reagent in various chemical reactions, such as the addition of nucleophiles and organometallic reagents, facilitating the synthesis of a wide range of organic compounds.
Used in Material Science:
5,5,5-Trifluoropent-1-en-4-ol has potential applications in the development of new materials, including fluorine-containing polymers, which can be utilized in various industries such as electronics, automotive, and aerospace.

InChI:InChI=1/C5H7F3O/c1-2-3-4(9)5(6,7)8/h2,4,9H,1,3H2

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 24850-33-7 allyltributylstanane 
• 421-53-4 2,2,2-trifluoro-1,1-ethanediol 
• 106-95-6 allyl bromide 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 
• 431-46-9 2,2,2-trifluoro-1-methoxy-ethanol 
• 762-72-1 allyl-trimethyl-silane 
• 1730-25-2 allylmagnesium bromide 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 

Relevant academic research and scientific papers

A versatile and practical synthesis of α-trifluoromethylated alcohols from trifluoroacetaldehyde ethyl hemiacetal in water

α-Trifluoromethylated alcohols via indium-mediated allylation of trifluoroacetaldehyde using a simple and practical preparation in water is described.

ORGANIC COMPOUNDS

Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be employed as inhibitors of other enzymes characterized with a phosphotyrosine binding region such as the SH2 domain. Accordingly, the compounds of formula (I) may be employed for prevention and/or treatment of insulin resistance associated with obesity, glucose intolerance, diabetes mellitus, hypertension and ischemic diseases of the large and small blood vessels, conditions that accompany type-2 diabetes, including hyperlipidemia, hypertriglyceridemia, atherosclerosis, vascular restenosis, irritable bowel syndrome, pancreatitis, adipose cell tumors and carcinomas such as liposarcoma, dyslipidemia, and other disorders where insulin resistance is indicated. In addition, the compounds of the present invention may be employed to treat and/or prevent cancer (such as prostate or breast cancer), osteoporosis, neurodegenerative and infectious diseases, and diseases involving inflammation and the immune system.

Towards the syntheses of α-trifluoromethylated oxygenated heterocycles and their precursors

The possibilities of synthesizing various α-trifluoro-methylated oxygenated heterocycles, starting from trifluoroacetaldehyde methyl hemiacetal, through classic cyclization reactions, have been demonstrated. In this way, six-membered cyclic compounds, δ-l

A simple and practical synthesis of α-trifluoromethylated alcohols in water

A simple and practical preparation of α-trifluoromethylated alcohols in water via indium-mediated allylation reaction and tin-mediated indium trichloride-promoted allylation reaction of trifluoroacetaldehyde hydrate and its ethyl hemiacetal is described in this paper.

Zinc bromide promoted allylation of aluminum acetals derived from perfluoro carboxylic acid esters and diisobutylaluminum hydride. New convenient access to α-perfluoroalkylated homoallyl alcohols

The reaction of aluminum acetals, generated in situ by the reduction between perfluoro carboxylic acid esters and diisobutylaluminum hydride, with a variety of allylstannanes efficiently proceeds in the presence of zinc bromide at 40°C to afford the corresponding α-perfluoroalkyl-substituted homoallyl alcohols in good yields.

Facile Synthesis of α-Trifluoromethylated Alcohols from Trifluoroacetaldehyde Ethyl Hemiacetal

Trifluoroacetaldehyde ethyl hemiacetal reacted with nucleophilic organosilanes such as cyanotrimethylsilane, allyltrimethylsilane, or enol trimethylsilyl ethers in the presence of Lewis acid to afford a series of α-trifluoromethylated alcohols in high yield. Key Words: trifluoroacetaldehyde ethyl hemiacetal; Lewis acid; trimethylsilylated nucleophiles; carbon-carbon bond formation; α-trifluoromethylated alcohol.

PREPARATION OF TRIFLUOROMETHYLATED ALLYLIC ALCOHOLS FROM TRIFLUOROACETALDEHYDE AND ORGANOMETALLIC COMPOUNDS

A number of allylic alcohols bearing a trifluoromethyl group at the α- or γ-position, and α-trifluoromethylated γ-enols and -ynols were prepared by the reaction of trifluoroacetaldehyde with a variety of organometallic compounds.Most of the Reformatsky- or Grignard-type reactions required promotion by ultrasonic irradiation.