77350-61-9

Upstream product

• 623-05-2 (4-hydroxyphenyl)methanol 
• 77350-58-4 [4-(4-Methyl-benzyloxy)-phenyl]-methanol 
• 104-81-4 4-Methylbenzyl bromide 
• 66742-58-3 4-((4-methylbenzyl)oxy)benzaldehyde 
• 108-88-3 toluene 
• 104-82-5 4-Methylbenzyl chloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 62290-48-6 4-(4-Methyl-benzyloxy)-benzoic acid methyl ester 

Downstream Products

• 77350-64-2 C₁₆H₁₈O₂ 

Relevant academic research and scientific papers

Design, synthesis, biological evaluation and structure-activity relationship of sophoridine derivatives bearing pyrrole or indole scaffold as potential antitumor agents

Taking sophoridine as a lead compound, 58 sophoridine derivatives were designed, synthesized and evaluated for their antiproliferative activity in the HepG2 cancer cell line. Among the 58 compounds, 33 compounds showed potent antiproliferative activity wi

Sophoridine pyrrole, indole derivative and preparation method and application thereof

The invention relates to a sophoridine pyrrole, indole derivative. The invention discloses a chemical structure of the compound and further discloses a preparation method of the compound. In vitro anti-tumor activity researches show that anti-tumor drugs

Methanolysis (Solvolysis) and Synthesis of 4'-Substituted 4-Benzyloxybenzyl Chlorides and Some Related Compounds: Comparisons with the Corresponding Benzoyl Compounds

The kinetics of methanolysis (solvolysis) in 97.4percent MeOH-dioxan of a series of 4'-substituted 4-benzyloxybenzyl chlorides, and of 4-anisyl, 4-phenoxybenzyl, and benzyl chlorides have been studied and discussed, including comparisons with the data for the corresponding series of benzoyl chlorides, previously reported by us.The 4'-substituted precursor alcohols, chlorides, and product methyl ethers are all new compounds. 4-Anisyl chloride and the series of benzyloxybenzyl chlorides react by the SN1 mechanism, whereas benzyl chloride react by the SN2 mechanism. 4-Phenoxybenzyl chloride shows intermediate behaviour.A similar pattern was observed with the corresponding benzoyl compounds.In both series the reactivity order is CH3O > 4'-CH3C6H4CH2O (-0.76) >C6H5CH2O (-0.74) > 4'-ClC6H4CH2O (-0.69) > 4'-NO2C6H4CH2O (-0.60) > C6H5O > H (values in paranthesis are new ?+ values).At 25 deg C the overall range of rates is 4290 in the benzyl series, compared with only 2.42 in the benzyl series.The Arrhenius parameters in the two series demonstrate, however, an underlying similarity with obvious differences superimposed.In both series, the introduction of 4-OR groups leads to a ΔS increase of ca. 40 J mol-1 K-1.In the benzyl series this is accompanied by ΔE decreases of ca. 6-10 kJ mol-1 whereas in the benzoyl series ΔE values increase by ca. 10-15 kJ mol-1.The equation log k = log k0 + n in mixtures with increasing content of dioxan, was used to study the rate dependence on MeOH concentration.Values of n are ca. 5 between 97.4 and 8.3percent MeOH, and ca. 3 between 83.3 and 50.0percent MeOH.