77375-79-2 Usage
Description
Ethyl 2-(isocyanatosulfonyl)benzoate is a chemical compound characterized by its molecular formula C11H11NO5S. It is a versatile reagent in organic synthesis, particularly for the preparation of a variety of functionalized compounds. The presence of the isocyanatosulfonyl group in its structure renders it a valuable building block for the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Additionally, it holds promise for the development of innovative materials and polymers. Due to its high reactivity, ethyl 2-(isocyanatosulfonyl)benzoate must be handled with caution in a controlled laboratory environment.
Uses
Used in Pharmaceutical Synthesis:
Ethyl 2-(isocyanatosulfonyl)benzoate is utilized as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of novel drug molecules. Its unique functional group facilitates the creation of diverse chemical entities with potential therapeutic applications.
Used in Agrochemical Development:
In the agrochemical industry, ethyl 2-(isocyanatosulfonyl)benzoate is employed as a building block for the synthesis of new agrochemicals. Its incorporation into these compounds can lead to the discovery of more effective and targeted pest control agents.
Used in Specialty Chemicals Production:
Ethyl 2-(isocyanatosulfonyl)benzoate is used as a reagent in the production of specialty chemicals, where its specific functional group can impart unique properties to the final products, enhancing their performance in various applications.
Used in Material and Polymer Development:
ethyl 2-(isocyanatosulfonyl)benzoate also serves as a component in the development of new materials and polymers, where its reactive nature and functional group can be leveraged to create materials with improved or novel characteristics for specific industries.
Check Digit Verification of cas no
The CAS Registry Mumber 77375-79-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,3,7 and 5 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 77375-79:
(7*7)+(6*7)+(5*3)+(4*7)+(3*5)+(2*7)+(1*9)=172
172 % 10 = 2
So 77375-79-2 is a valid CAS Registry Number.
77375-79-2Relevant articles and documents
Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase
Lee, Yu-Ting,Cui, Chang-Jun,Chow, Eve W. L.,Pue, Nason,Lonhienne, Thierry,Wang, Jian-Guo,Fraser, James A.,Guddat, Luke W.
, p. 210 - 219 (2013/02/23)
The sulfonylurea herbicides exert their activity by inhibiting plant acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthesis pathway. It has previously been shown that if the gene for AHAS is deleted in Candida albicans, attenuation of virulence is achieved, suggesting AHAS as an antifungal drug target. Herein, we have cloned, expressed, and purified C. albicans AHAS and shown that several sulfonylureas are inhibitors of this enzyme and possess antifungal activity. The most potent of these compounds is ethyl 2-(N-((4-iodo-6-methoxypyrimidin-2-yl)carbamoyl) sulfamoyl)benzoate (10c), which has a Ki value of 3.8 nM for C. albicans AHAS and an MIC90 of 0.7 μg/mL for this fungus in cell-based assays. For the sulfonylureas tested there was a strong correlation between inhibitory activity toward C. albicans AHAS and fungicidal activity, supporting the hypothesis that AHAS is the target for their inhibitory activity within the cell.
Intermediates for herbicidal sulfonamides
-
, (2008/06/13)
This invention relates to novel o-carbonylbenzenesulfonyl isocyanates and their use as intermediates for the preparation of sulfonylureas which are known to be active herbicides.
