77378-64-4Relevant academic research and scientific papers
Neuroleptics from the 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyridoindole Series. 3. Carboxamidoalkyl Derivatives
Welch, Willard M.,Harbert, Charles A.,Sarges, Reinhard,Weissman, Albert,Koe, B. Kenneth
, p. 2108 - 2111 (2007/10/02)
Substitution of position 2 of the 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyridoindole nucleus with ω-carboxamidoalkyl substituents leads to compounds with exceedingly potent neuroleptic activity in in vitro and in vivo models.Although duration of a
Neuroleptic Activity of Chiral trans-Hexahydro-γ-carbolines
Sarges, Reinhard,Howard, Harry R.,Donahue, Kathy M.,Welch, Williard M.,Dominy, Beryl W.,et al.
, p. 8 - 19 (2007/10/02)
A series of trans-8-fluoro-5-(4-fluorophenyl)-2,3,4,4a,5,9b-hexahydro-1H-pyridoindoles with various N-2 substituents has been prepared and tested for neuroleptic activity (3H>spiroperidol binding and amphetamine antagonism).Several memb
