77407-03-5Relevant academic research and scientific papers
Et3B-mediated palladium-catalyzed direct allylic substitution reactions of Morita–Baylis–Hillman alcohols with aromatic amines
Abidi, Ahlem,Oueslati, Yosra,Rezgui, Farhat
, p. 1916 - 1923 (2016)
An efficient, direct allylic amination of both cyclic and acyclic Morita–Baylis–Hillman alcohols with aromatic amines, in tetrahydrofuran (THF) at room temperature, catalyzed by Pd(0)/Et3B, is reported herein. The corresponding amines are obtained with a high α -regioselectivity in 65–87% yields.
Transition-metal-free nucleophilic allylic substitutions of Morita–Baylis–Hillman bromides with aliphatic and aromatic amines
Baioui, Narjes,Elleuch, Haitham,Rezgui, Farhat
, p. 1796 - 1802 (2016/11/18)
A simple protocol for the preparation of functionalized allylic amines under mild, transition-metal-free conditions from the reaction of Morita–Baylis–Hillman (MBH) bromides with amines is described herein. The treatment of the MBH bromides with various amines in the presence of NaI and Et3N in aqueous acetone solution and at room temperature affords the corresponding functionalized allyl amines in moderate to good yields (45–87%). The reaction is rapid and carried out at room temperature.
REGIOSPECIFIC CARBON-CARBON BOND FORMATION AT α AND β POSITIONS IN CYCLIC KETONES VIA DOUBLE MICHAEL ADDITION TO α-METHYLENE-β-ALKOXY CYCLIC KETONE
Takahashi, Takashi,Hori, Kimihiko,Tsuji, Jiro
, p. 119 - 122 (2007/10/02)
Very reactive 2-methylene-3-alkoxycyclohexanone was synthesized.The 1,4-conjugate addition of various nucleophiles to this enone gave only β'-alkylated 2-cyclohexenone with simultaneous elimination of the β-alkoxy group.The second 1,4-conjugate addition of other nucleophile to the resulting cyclohexenone leads to the α and β disubstituted ketones.
