774181-71-4Relevant academic research and scientific papers
Synthesis of the Natural Product Iotrochamide B
Wang,Zhao,Que
, p. 499 - 501 (2019/07/02)
Iotrochamide B is the first cinnamoyl amino acid reported from the marine sponge Iotrochota sp. The total synthesis of the marine indole alkaloid iotrochamide B was achieved by condensation of 6-bromo-L-tryptophan (3) and (Z)-2-methoxy-3-phenylacrylic acid (6). The key step was the synthesis of 6-bromo-L-tryptophan ((S)-3) from racemic N-acetyltryptophan by optical resolution using (S)-(–)-1-phenylethylamine. This work provides an efficient method for future synthesis of iotrochamide B derivatives.
COMPOUNDS AND METHOD OF USE
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Paragraph 1153, (2019/09/06)
This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.
Total synthesis of (-)-aspergilazine A
Boyd, Emily M.,Sperry, Jonathan
supporting information, p. 5056 - 5059 (2015/02/19)
The total synthesis of (-)-aspergilazine A, an alkaloid possessing a rare N1′ to C6 bisindole bond, is described. A palladium-catalyzed N-arylation was used to selectively install the N1′-C6 bond in the presence of three other possible arylation sites. The ligand XPhos displayed a unique capability to efficiently carry out the N-arylation while simultaneously suppressing epimerization of the sensitive C9 stereocenters. This total synthesis has confirmed that aspergilazine A is a dimer of brevianamide F.
