774181-71-4

Basic information

• Product Name: 6-Bromotryptophan methyl ester
• Synonyms: 6-Bromotryptophan methyl ester;Tryptophan, 6-bromo-, methyl ester
• CAS NO: 774181-71-4
• Molecular Formula: C12H13BrN2O2
• Molecular Weight: 297.15
• Mol File: 774181-71-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.552
• CAS DataBase Reference: 6-Bromotryptophan methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromotryptophan methyl ester(774181-71-4)
• EPA Substance Registry System: 6-Bromotryptophan methyl ester(774181-71-4)

Safety Data

• Hazardous Substances Data: 774181-71-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 496930-10-0 6'-bromo-D-tryptophan 
• 496930-11-1 N^α-acetyl-6-bromo-L-tryptophan 
• 52415-29-9 6-bromo-1H-indole 
• 52448-17-6 (2S)-2-amino-3-(6-bromo-1H-indol-3-yl)propanoic acid 
• 85515-06-6 N^α-acetyl-6-bromo-D,L-tryptophan 

Relevant articles and documents

COMPOUNDS AND METHOD OF USE

This present disclosure relates to compounds with ferroptosis inducing activity, a method of treating a subject with cancer with the compounds, and combination treatments with a second therapeutic agent.

Total synthesis of (-)-aspergilazine A

The total synthesis of (-)-aspergilazine A, an alkaloid possessing a rare N1′ to C6 bisindole bond, is described. A palladium-catalyzed N-arylation was used to selectively install the N1′-C6 bond in the presence of three other possible arylation sites. The ligand XPhos displayed a unique capability to efficiently carry out the N-arylation while simultaneously suppressing epimerization of the sensitive C9 stereocenters. This total synthesis has confirmed that aspergilazine A is a dimer of brevianamide F.