77429-98-2

Upstream product

• 77429-97-1 N¹,N⁵-ditosyl-3-azapentane-1,5-diamine 
• 98-88-4 benzoyl chloride 
• 14316-16-6 N-tosylethylenediamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 6367-75-5 2-(tosylamino)ethyl p-toluenesulfonate 
• 3634-89-7 N-(p-toluenesulfonyl)aziridine 

Downstream Products

• 107098-13-5 7,9-dibenzoyl-4,10,16,22-tetrakis-(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane 
• 77429-96-0 N'-benzoyl-N,N-bis(p-tolylsulfonyl)diethylenetriamine N,N-disodium salt 
• 107098-11-3 9-benzoyl-6,12-bis(p-tolylsulfonyl)-6,9,12-triaza-3,15-dioxaheptadecane-1,17-diol 
• 593284-42-5 1-benzoyl-4,7,10,13,16-pentatosyl-1,4,7,10,13,16-hexaazacyclooctadecane 
• 593284-43-6 7-benzoyl-1,4,10,13,17-pentatosyl-1,4,7,10,13,17-hexaazacycloicosane 
• 164913-36-4 N¹,N⁴,N⁷,N¹⁰,N¹³-pentatosyl-1,4,7,10,13,16-hexaazacyclooctadecane 
• 593284-44-7 1,4,10,13,17-pentatosyl-1,4,7,10,13,17-hexaazacycloicosane 
• 593284-46-9 1-(N-tosyl-2-aminoethyl)-4,7,10,13,16-pentatosyl-1,4,7,10,13,16-hexaazacyclooctadecane 
• 593284-47-0 7-(N-tosyl-2-aminoethyl)-1,4,10,13,17-pentatosyl-1,4,7,10,13,17-hexaazacycloicosane 
• 64844-66-2 4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane 
• 107098-17-9 4,10,16,19,22-pentakis(p-tolylsulfonyl)-1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane 
• 107098-14-6 7,19-bis<2-ethyl>-4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane 
• 107098-18-0 7-<2-ethyl>-4,10,16,19,22-pentakis(p-tolylsulfonyl)-1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane 
• 107098-12-4 9-benzoyl-6,12-bis(p-tolylsulfonyl)-1,17-bis(mesyloxy)-6,9,12-triaza-3,15-dioxaheptadecane 

Relevant academic research and scientific papers

Preparation of hexaaza and heptaaza macrocycles functionalized with a single aminoalkyl pendant arm

A practical and reproducible route for the preparation of 1,4,7,10,13,16,19-heptaazacyclohenicosane (1), 1,4,7,10,13,16-hexaazacyclooctadecane (2), and 1,4,7,10,13,17-hexaazacycloicosane (3) bearing a single N-(2-amino-ethyl) pendant arm has been develope

Synthesis of Selectively Protected Tri- and Hexaamine Macrocycles

A general route to tri- and hexaamine macrocycles containing selectively protected diethylenetriamine units has been developed.Condensation of the N'-benzoyl-N,N"-bis(p-tolylsulfonyl)diethylenetriamine N,N"-disodium salt with bissulfonate esters of two-, four-, and six-carbon diols at high reactant concentrations gave the corresponding 9- and 18- (85percent and 1percent), 11- and 22- (30percent and 20percent), and 13- and 26- (56percent and 17percent) membered tri- and hexaamine macrocycles, respectively.The benzoyl group was selectively removed with potassium tert-butoxide in ca. 90percent yield, and the macrocycles were conveniently separated by chromatography.Details of the synthetic procedures and characterization of the new selectively protected tri- and hexaamine macrocycles are described.