77429-98-2

Upstream product

• 3634-89-7 N-(p-toluenesulfonyl)aziridine 
• 14316-16-6 N-tosylethylenediamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 6367-75-5 2-(tosylamino)ethyl p-toluenesulfonate 
• 98-88-4 benzoyl chloride 
• 77429-97-1 N¹,N⁵-ditosyl-3-azapentane-1,5-diamine 

Downstream Products

• 107098-13-5 7,9-dibenzoyl-4,10,16,22-tetrakis-(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane 
• 77429-96-0 N'-benzoyl-N,N-bis(p-tolylsulfonyl)diethylenetriamine N,N-disodium salt 
• 107098-11-3 9-benzoyl-6,12-bis(p-tolylsulfonyl)-6,9,12-triaza-3,15-dioxaheptadecane-1,17-diol 
• 593284-42-5 1-benzoyl-4,7,10,13,16-pentatosyl-1,4,7,10,13,16-hexaazacyclooctadecane 
• 593284-43-6 7-benzoyl-1,4,10,13,17-pentatosyl-1,4,7,10,13,17-hexaazacycloicosane 
• 77429-91-5 4-benzoyl-1,7-bis(p-tolylsulfonyl)-1,4,7-triazacycloundecane 
• 77429-92-6 4-benzoyl-1,7-bis(p-tolylsulfonyl)-1,4,7-triazacyclotridecane 
• 118852-33-8 4,13-dibenzoyl-1,7,10,16-tetrakis(p-tolylsulfonyl)-1,4,7,10,13,16-hexaazacyclooctadecane 
• 77429-93-7 4,15-dibenzoyl-1,7,12,18-tetrakis(p-tolylsulfonyl)-1,4,7,12,15,18-hexaazacyclodocosane 
• 77429-94-8 4,17-dibenzoyl-1,7,14,20-tetrakis(p-tolylsulfonyl)-1,4,7,14,17,20-hexaazacyclohexacosane 
• 107098-16-8 7-benzoyl-4,10,16,19,22-pentakis(p-tolylsulfonyl)-1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane 
• 107098-22-6 7-(2-mercaptoethyl)-4,10,16,19,22-pentakis(p-tolylsulfonyl)-1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane 
• 107098-21-5 7-(2-hydroxyethyl)-4,10,16,19,22-pentakis(p-tolylsulfonyl)-1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane 
• 107098-19-1 7,19-bis(2-hydroxyethyl)-4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane 

Relevant academic research and scientific papers

Preparation of hexaaza and heptaaza macrocycles functionalized with a single aminoalkyl pendant arm

A practical and reproducible route for the preparation of 1,4,7,10,13,16,19-heptaazacyclohenicosane (1), 1,4,7,10,13,16-hexaazacyclooctadecane (2), and 1,4,7,10,13,17-hexaazacycloicosane (3) bearing a single N-(2-amino-ethyl) pendant arm has been develope

Synthesis of Selectively Protected Tri- and Hexaamine Macrocycles

A general route to tri- and hexaamine macrocycles containing selectively protected diethylenetriamine units has been developed.Condensation of the N'-benzoyl-N,N"-bis(p-tolylsulfonyl)diethylenetriamine N,N"-disodium salt with bissulfonate esters of two-, four-, and six-carbon diols at high reactant concentrations gave the corresponding 9- and 18- (85percent and 1percent), 11- and 22- (30percent and 20percent), and 13- and 26- (56percent and 17percent) membered tri- and hexaamine macrocycles, respectively.The benzoyl group was selectively removed with potassium tert-butoxide in ca. 90percent yield, and the macrocycles were conveniently separated by chromatography.Details of the synthetic procedures and characterization of the new selectively protected tri- and hexaamine macrocycles are described.