774513-65-4Relevant academic research and scientific papers
MORPHINAN DERIVATIVES AS ANTI-ITCHING AGENT
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Page/Page column 41, (2008/06/13)
A novel antipruritic useful for the treatment of pruritus accompanying various diseases is disclosed. The antipruritic comprises a specific morphinan derivative having a nitrogen-containing cyclic group or the pharmaceutically acceptable acid addition salt thereof such as N-(17-cyclopropylmethyl-4,5±-epoxy-3,14-dihydroxy-morphinan-62-yl)-phthalimide hydrochloric acid salt or N-( 17-cyclopropylmethyl-4,5±-epoxy-3,14-dihydroxy-morphinan-62-yl)-3,4,5,6-tetrahydrophthalimide tartaric acid salt.
Morphinan derivatives and pharmaceutical use thereof
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, (2008/06/13)
A morphinan derivative or its pharmaceutically acceptable acid addition salt represented with, for example, and an analgesic, diuretic, antitussive and brain cell protector having its derivative or its salt as the active ingredient are described. The compound of the present invention possesses strong analgesic activity, diuretic action and antitussive action as a highly selective κ-opioid agonist, allowing it to be used as a useful analgesic, diuretic and antitussive. On the other hand, the compound of the present invention also possesses remarkable cerebro-neuroprotective activity, thus allowing it be used as a useful cerebro-neuroprotective agents.
Morphinan derivative and its pharmaceutical applications
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, (2008/06/13)
A morphinan derivative or its pharmacologically allowed acid addition salt represented with compound I, an analgesic and diuretic having its derivative or its salt as the active ingredient, and its production process are described. The compound of the present invention possesses strong analgesic activity and diuretic action as a highly selective κ-opioid agonist, allowing it to be used as a useful analgesic and diuretic.
Antitussive agents
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, (2008/06/13)
There are provided novel antitussive agents different from existing antitussive agents or those under development. Antitussive agents containing morphinan derivatives represented by compound 6: STR1 or pharmacologically acceptable acid-addition salts thereof and those derivatives or their salts as effective components. The antitussive agents according to the present invention have strong antitussive effects as highly selective κ-opioid agonists, and may thus be applied as useful antitussive agents in the prophylaxis and treatment of coughing in a patient in need thereof.
