77455-52-8

Upstream product

• 50907-46-5 5-(2-chlorophenyl)-1H-tetrazole 
• 74-88-4 methyl iodide 
• 616-38-6 carbonic acid dimethyl ester 
• 873-32-5 2-Chlorobenzonitrile 
• 3400-31-5 2-chloro-N-methylbenzamide 

Downstream Products

• 1334306-25-0 5-(2-(diphenylphosphino)phenyl)-1-methyl-1H-tetrazole 
• 1415801-88-5 C₂₀H₁₇N₄OP 

Relevant academic research and scientific papers

An Environmentally Friendly Method for N-Methylation of 5-Substituted 1H-Tetrazoles with a Green Methylating Reagent: Dimethyl Carbonate

An environmentally friendly method was established for the N-methylation of the 5-substituted 1H-tetrazoles with a green reagent: DMC. DABCO was the optimal catalyst, and hazardous chemicals were avoided in this protocol. A plausible catalytic mechanism is proposed, which consists of a DABCO-activated process and a thermally induced rearrangement of tetrazole carbamates.

A Study of Annular Tautomerism, Interannular Conjugation, and Methylation Reactions of ortho-Substituted-5-aryltetrazoles using Carbon-13 and Hydrogen-1 N.M.R. Spectroscopy

In ortho-substituted-5-phenyltetrazoles, Ar-CN4H (Ar = 2'-MeC6H4, 2'-ClC6H4, or 2',6'-Cl2C6H3), the rings are twisted out of the planar configuration and interannular conjugation is inhibited.In each case the tetrazole 1-NH tautomer is strongly predominan