3400-31-5

Usage

Uses

Used in Pharmaceutical Industry:
NSC406902 is used as a potential anticancer agent for its ability to inhibit the growth of tumor cells. It has shown promising anticancer activity in preclinical studies, making it a candidate for further research and development in cancer treatment.
Used in Medical Research:
NSC406902 is used as a subject of study for its potential therapeutic properties in the treatment of infectious diseases. Its demonstrated antimicrobial activity against certain pathogens highlights its potential as a new drug candidate for combating infections.
Used in Drug Development:
NSC406902 is used as a compound of interest in the development of new pharmaceuticals. Ongoing research aims to explore its potential applications in various medical fields, including the enhancement of its delivery, bioavailability, and therapeutic outcomes through novel drug delivery systems.

InChI:InChI=1/C8H8ClNO/c1-10-8(11)6-4-2-3-5-7(6)9/h2-5H,1H3,(H,10,11)

Upstream product

• 609-66-5 2-chlorobenzamide 
• 74-88-4 methyl iodide 
• 109-09-1 2-chloropyridine 
• 289686-74-4 2‐chloro‐N‐methoxy‐N‐methylbenzamide 
• 609-65-4 o-chlorobenzoyl chloride 
• 88070-48-8 N-methylbenzamide 
• 593-51-1 methylamine hydrochloride 
• 30004-67-2 N,S-dimethyl-S-phenylsulfoximine 
• 89-98-5 2-chloro-benzaldehyde 
• 610-96-8 methyl chlorobenzoate 
• 74-89-5 methylamine 
• 118-91-2 ortho-chlorobenzoic acid 
• 28123-61-7 N-Benzyl-N-methyl-o-chlorbenzamid 
• 7147-44-6 1-(2-chlorophenyl)ethanone oxime 

Downstream Products

• 127787-40-0 2-Chloro-N-methyl-N-trimethylsilanylmethyl-benzamide 
• 225516-08-5 3-(3-bromo-4,5-dimethoxyphenyl)-7-chlorophthalide 
• 212501-02-5 N-methyl-2-chloro-6-[hydroxy-(3,4,5-trimethoxyphenyl)methyl]benzamide 
• 880166-80-3 ethyl 1-[5-(2-chlorophenyl)-4-methyl-1,2,4-triazol-3-yl]cyclobutanecarboxylate 
• 2527-66-4 2-methyl-1,2-benzisothiazole-3(2H)-one 
• 1384754-90-8 trans-[(C₆H₄C(O)NHMe)Ni(II)(trimethylphosphine)2Cl] 
• 127818-28-4 2-Chloro-6-formyl-N-methyl-N-trimethylsilanylmethyl-benzamide 
• 200411-11-6 N-(2-chlorobenzoyl)-N-methylaminomethyl phenyl sulfone 
• 200411-13-8 3-Benzenesulfonyl-2-methyl-2,3-dihydro-isoindol-1-one 
• 225517-53-3 1-(3-bromo-4,5-dimethoxyphenyl)-5-chloro-2,3-bis(methoxycarbonyl)naphthalene 

Relevant academic research and scientific papers

The Pd-catalyzed synthesis of difluoroethyl and difluorovinyl compounds with a chlorodifluoroethyl iodonium salt (CDFI)

Herein, we report a simple and efficient method for the direct installation of chlorodifluoroethyl group onto aromatic molecules of various aromatic amides with a new 2-chloro,2,2-difluoroethyl(mesityl)iodonium salt (CDFI). Moreover, the chlorodifluoroeth

Catalytic asymmetric [3+2] cycloaddition of isomünchnones with methyleneindolinones

An efficient enantioselective [3+2] cycloaddition of isomünchnones with methyleneindolinones that are generated by anin situintramolecular addition of the carbonyl group to rhodium carbenes is realized with a chiralN,N′-dioxide/Zn(ii) complex as a Lewis acid. A series of chiral oxa-bridged 3-spiropiperidines are obtained in high yields with excellent dr and excellent ee values.

Formation of Aryl [1-Cyano-4-(dialkylamino)butadienyl] Ketones from Pyridines

Treatment of 2-chloropyridine with LDA and the Weinreb amide of benzoic acid afforded three unusual products, namely N -methylbenzamide, 2-chloropyridine-3-methanol, and the ring-opened addition product. This same final product could also be obtained from 2-chloro-3-benzoylpyridine on treatment with LDA. Mechanistic insight for the formation of these products is provided.

Nickel-catalyzed regioselective C-H halogenation of electron-deficient arenes

A straightforward Ni(ii)-catalyzed general strategy was developed for the ortho-halogenation of electron-deficient arenes with easily available halogenating reagents N-halosuccinimides (NXS; X = Br, Cl and I). The transformation was highly regioselective and a wide substrate scope and functional group tolerance were observed. This discovery could be of great significance for the selective halogenation of amides, benzoic esters and other substances with guiding groups. Mechanistic investigations were also described.

Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.

Ru(II)-Catalyzed C-H Activation: Amide-Directed 1,4-Addition of the Ortho C-H Bond to Maleimides

Maleimide has been used as a selective coupling partner to generate conjugate addition products exclusively. The typical Heck-type oxidative coupling that occurs when alkenes are used is avoided by choosing maleimide as an alkene, which cannot undergo β-hydride elimination due to the unavailability of a syn-periplanar β-hydrogen atom. The amide nitrogen, which is notorious for undergoing tandem reactions to generate spirocyclic or annulation products under cross-coupling conditions, remains innocent in this report. Along with the substrate scope, a robustness screen has been performed to analyze the performance of amide as a directing group in the presence of other directing groups and also to examine the tolerance of the reaction conditions for other frequently encountered functional groups.

Iron-Catalyzed Acylative Dealkylation of N-Alkylsulfoximines

As a result of our recent investigations into the N-functionalization of sulfoximines, an iron-catalyzed dealkylative acylation of N-alkylsulfoximines has been developed. This process involves a Polonovski-type dealkylation of an N-alkylated sulfoximine to afford a reactive intermediate that is trapped in the presence of a suitable aldehyde or anhydride to afford N-acyl- and N-aroylsulfoximine derivatives in one pot. Subsequent cleavage of the acyl or aroyl group under acidic conditions generates a synthetically valuable NH-sulfoximine. The dealkylation of N-alkylsulfoximines has been developed utilizing TBHP as oxidant and a catalytic amount of iron chloride to furnish a range of N-acyl- and N-aroylsulfoximines. This method facilitates the use of N-alkyl protecting groups that provide very stable N-protected sulfoximine derivatives that can be readily modified at sites other than the nitrogen atom.

Bis-aryl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1

3-Aryl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). They are active in both in vitro and an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relatio

Room-temperature debenzylation of N-benzylcarboxamides by N-bromosuccinimide

A simple and highly efficient method has been developed with which to cleave the N-benzyl group on N-mono- or disubstituted carboxamides using N-bromosuccinimide (NBS) at room temperature. All the 31 substrates examined showed moderate to excellent deprotection yields. Our study also indicated that the debenzylation may involve an oxygen/light initiated free radical mechanism. Georg Thieme Verlag Stuttgart.

Efficient Beckmann rearrangement and dehydration of oximes via phosphonate intermediates

Under mild conditions, conversion of a variety of ketoximes and aldoximes to their corresponding amides and nitriles proceeded in the presence of diethyl chlorophosphate with excellent yields.